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Titre du document / Document title

Cellular immunity to mumps virus in young adults 21 years after measles-mumps-rubella vaccination

Auteur(s) / Author(s)

JOKINEN Sari (1) ; ÖSTERLUND Pamela (1) ; JULKUNEN Ilkka (1) ; DAVIDKIN Irja (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, FINLANDE

Résumé / Abstract

Background. Measles-mumps-rubella (MMR) vaccination has decreased the incidence of measles, mumps, and rubella virus infections in several countries. However, the persistence of MMR vaccine-induced immunity in the absence of endemic infection has remained unknown. Methods. The persistence of cellular and humoral immunity to mumps virus was studied in 50 individuals (group A) who had been vaccinated twice with MMR vaccine during early childhood and were followed up for 21 years after their first vaccination. Eleven individuals (group B) with naturally acquired immunity to mumps virus were studied for comparison. Results. Anti-mumps virus IgG antibodies were detectable (titer ≥230) in 72% of the vaccinees. A mumps antigen-specific lymphoproliferative response (defined as a stimulatory index [SI] ≥3) was observed in 98% of group A subjects (mean ± SD SI, 26 ± 30 [range, 0.5-252]) and in 100% of group B subjects (mean ± SD SI, 22 ± 27 [range, 5-123]). Significant mumps antigen-specific interferon-γ production was detected in 73% of subjects in both groups A and B, and interleukin-10 production was detected in 40% and 36% of group A and B subjects, respectively. Conclusions. All presently seronegative vaccinees (n = 14) had mumps antigen-specific lymphoproliferative responses, and only 1 of the seropositive vaccinees (n = 36) was devoid of detectable cellular immunity. The results suggest a very long persistence of vaccine-induced anti-mumps virus cellular immunity.

Revue / Journal Title

The Journal of infectious diseases    ISSN  0022-1899   CODEN JIDIAQ 

Source / Source

2007, vol. 196, no6, pp. 861-867 [7 page(s) (article)] (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

Oxford University Press, Oxford, ROYAUME-UNI  (1904) (Revue)

Mots-clés anglais / English Keywords

Infection

;

Viral disease

;

Human

;

Virus

;

Mononegavirales

;

Paramyxoviridae

;

Paramyxovirinae

;

Rubulavirus

;

Mumps

;

Measles

;

Vaccination

;

Rubella

;

Young adult

;

Cellular immunity

;

Mumps virus

;

Mots-clés français / French Keywords

Infection

;

Virose

;

Homme

;

Virus

;

Mononegavirales

;

Paramyxoviridae

;

Paramyxovirinae

;

Rubulavirus

;

Oreillons

;

Rougeole

;

Vaccination

;

Rubéole

;

Adulte jeune

;

Immunité cellulaire

;

Virus oreillons

;

Mots-clés espagnols / Spanish Keywords

Infección

;

Virosis

;

Hombre

;

Virus

;

Mononegavirales

;

Paramyxoviridae

;

Paramyxovirinae

;

Rubulavirus

;

Paperas

;

Sarampión

;

Vacunación

;

Rubeola

;

Adulto joven

;

Inmunidad celular

;

Mumps virus

;

Localisation / Location

INIST-CNRS, Cote INIST : 2052, 35400016083439.0070

Nº notice refdoc (ud4) : 19060889



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