Titre du document / Document title
Long-term results of liver transplantation for hepatocellular carcinoma : An update of the university of padova experience
Auteur(s) / Author(s)
VITALE A. (1) ;
GRINGERI E. (2) ;
VALMASONI M. (2) ;
D'AMICO F. (2) ;
CARRARO A. (2) ;
PAULETTO A. (2) ;
D'AMICO F. J. (2) ;
POLACCO M. (2) ;
D'AMICO D. F. (2) ;
CILLO U. (2) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Unità di Chirurgia Oncologica Istituto Oncologico Veneto, IOV-IRCCS, Padova, ITALIE
(2) Unità di Chirurgia Epatobiliare e Trapianto Epatico Universitá -Dipartimento assistenziale di Chirurgia Generale e Trapianti d'Organo-Università, Azienda Ospedaliera di Padova, Padova, ITALIE
Résumé / Abstract
Background. Hepatocellular carcinoma (HCC) competes with benign liver disease as indication for liver transplantation (OLT). The aim of this study was to determine long-term results of OLT for HCC. Methods. We retrospectively analyzed the prognostic role of HCC diagnosis at pathological exam in adult OLT. In the HCC group, we evaluated the prognostic role of the time of diagnosis (incidental versus nonincidental) and of pathological tumor TNM staging. The primary endpoint was 1-, 3-, and 10-year patient survivals. Results. From 1991 to 2006, among 550 adults who underwent first OLT, HCC was found in 120 patients at pathological exam. In 26 cases (22%), the diagnosis of HCC was incidental. There were 59 cases (49%) of pathological T1 to T2 tumor (one nodule < 5 cm, or two to three nodules < 3 cm, without metastases and/or vascular invasion), and 61 cases (51%) of pathologic T3-T4a tumor. HCC diagnosis did not show a significant prognostic impact by Cox survival analysis. After a median follow-up of 31 months, 1-, 5-, and 10-year survivals were 91%, 81%, and 73% in the HCC group, and 84%, 76%, and 67% in the non-HCC group. Time of HCC diagnosis (incidental versus nonincidental) and pathological TNM staging (T1 to T2 vs T3 to T4a) did not result significant survival predictors upon Cox analysis. Conclusion. In our experience, the long-term results of OLT for HCC overlapped those of OLT for benign disease, although 51% of tumors were T3 to T4a at pathological exam.
Revue / Journal Title
Transplantation proceedings
ISSN
0041-1345
CODEN TRPPA8
Source / Source
Congrès
Congress of the Italian Society of Transplantation N
o30, Padova
, ITALIE
(30/11/2006)
2007, vol. 39, n
o 6 (329 p.) [Document : 3 p.] (15 ref.), pp. 1892-1894 [3 page(s) (article)]
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Amsterdam, PAYS-BAS
(1969)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 14765, 35400014662556.0460
Nº notice refdoc (ud4) : 19021177
