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Titre du document / Document title

Long-term results of liver transplantation for hepatocellular carcinoma : An update of the university of padova experience

Auteur(s) / Author(s)

VITALE A. (1) ; GRINGERI E. (2) ; VALMASONI M. (2) ; D'AMICO F. (2) ; CARRARO A. (2) ; PAULETTO A. (2) ; D'AMICO F. J. (2) ; POLACCO M. (2) ; D'AMICO D. F. (2) ; CILLO U. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Unità di Chirurgia Oncologica Istituto Oncologico Veneto, IOV-IRCCS, Padova, ITALIE
(2) Unità di Chirurgia Epatobiliare e Trapianto Epatico Universitá -Dipartimento assistenziale di Chirurgia Generale e Trapianti d'Organo-Università, Azienda Ospedaliera di Padova, Padova, ITALIE

Résumé / Abstract

Background. Hepatocellular carcinoma (HCC) competes with benign liver disease as indication for liver transplantation (OLT). The aim of this study was to determine long-term results of OLT for HCC. Methods. We retrospectively analyzed the prognostic role of HCC diagnosis at pathological exam in adult OLT. In the HCC group, we evaluated the prognostic role of the time of diagnosis (incidental versus nonincidental) and of pathological tumor TNM staging. The primary endpoint was 1-, 3-, and 10-year patient survivals. Results. From 1991 to 2006, among 550 adults who underwent first OLT, HCC was found in 120 patients at pathological exam. In 26 cases (22%), the diagnosis of HCC was incidental. There were 59 cases (49%) of pathological T1 to T2 tumor (one nodule < 5 cm, or two to three nodules < 3 cm, without metastases and/or vascular invasion), and 61 cases (51%) of pathologic T3-T4a tumor. HCC diagnosis did not show a significant prognostic impact by Cox survival analysis. After a median follow-up of 31 months, 1-, 5-, and 10-year survivals were 91%, 81%, and 73% in the HCC group, and 84%, 76%, and 67% in the non-HCC group. Time of HCC diagnosis (incidental versus nonincidental) and pathological TNM staging (T1 to T2 vs T3 to T4a) did not result significant survival predictors upon Cox analysis. Conclusion. In our experience, the long-term results of OLT for HCC overlapped those of OLT for benign disease, although 51% of tumors were T3 to T4a at pathological exam.

Revue / Journal Title

Transplantation proceedings    ISSN  0041-1345   CODEN TRPPA8 

Source / Source

Congrès
Congress of the Italian Society of Transplantation No30, Padova , ITALIE (30/11/2006)
2007, vol. 39, no 6 (329 p.)  [Document : 3 p.] (15 ref.), pp. 1892-1894 [3 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1969) (Revue)

Mots-clés anglais / English Keywords

Malignant tumor

;

Digestive diseases

;

Digestive system

;

Surgery

;

Hepatic disease

;

Liver transplantation

;

Treatment

;

Graft

;

Medicine

;

Liver cancer

;

Experience

;

University

;

Hepatocellular carcinoma

;

Long term

;

Prognosis

;

Homotransplantation

;

Mots-clés français / French Keywords

Tumeur maligne

;

Appareil digestif pathologie

;

Appareil digestif

;

Chirurgie

;

Foie pathologie

;

Transplantation hépatique

;

Traitement

;

Greffe

;

Médecine

;

Cancer foie

;

Expérience

;

Université

;

Carcinome hépatocellulaire

;

Long terme

;

Pronostic

;

Homotransplantation

;

Mots-clés espagnols / Spanish Keywords

Tumor maligno

;

Aparato digestivo patología

;

Aparato digestivo

;

Cirugía

;

Hígado patología

;

Tratamiento

;

Injerto

;

Medicina

;

Cáncer del hígado

;

Experiencia

;

Universidad

;

Carcinoma hepatocelular

;

Largo plazo

;

Pronóstico

;

Homotrasplante

;

Localisation / Location

INIST-CNRS, Cote INIST : 14765, 35400014662556.0460

Nº notice refdoc (ud4) : 19021177



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