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Titre du document / Document title

Bone marrow-derived cells: The influence of aging and cellular senescence

Auteur(s) / Author(s)

BEAUSEJOUR C. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pharmacology, University de Montreal & Centre Hospitalier Universitaire Sainte-Justine, 3175 Cote Ste-Catherine Road, Montreal QC, H3T 1C5, CANADA

Résumé / Abstract

During the course of an entire lifespan, tissue repair and regeneration is made possible by the presence of adult stem cells. Stem cell expansion, maintenance, and differentiation must be tightly controlled to assure longevity. Hematopoietic stem cells (HSC) are greatly solicited given the daily high blood cell turnover. Moreover, several bone marrow-derived cells including HSC, mesenchymal stromal cells (MSC), and endothelial progenitor cells (EPC) also significantly contribute to peripheral tissue repair and regeneration, including tumor formation. Therefore, factors influencing bone marrow-derived cell proliferation and functions are likely to have a broad impact. Aging has been identified as one of these factors. One hypothesis is that aging directly affects stem cells as a consequence of exhaustive proliferation. Alternatively, it is also possible that aging indirectly affects stem cells by acting on their microenvironment. Cellular senescence is believed to have evolved as a tumor suppressor mechanism capable of arresting growth to reduce risk of malignancy. In opposition to apoptosis, senescent cells accumulate in tissues. Recent evidence suggests their accumulation contributes to the phenotype of aging. Senescence can be activated by both telomere-dependent and telomere-independent pathways. Genetic alteration, genome-wide DNA damage, and oxidative stress are inducers of senescence and have recently been identified as occurring in bone marrow-derived cells. Below is a review of the link between cellular senescence, aging, and bone marrow-derived cells, and the possible consequences aging may have on bone marrow transplantation procedures and emerging marrow-derived cell-based therapies.

Revue / Journal Title

Handbook of experimental pharmacology    ISSN  0171-2004 

Source / Source

2007, vol. 180 (294 p.)  [Document : 22 p.] (5 p.1/4), pp. 67-88 [22 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Springer, Heidelberg, ALLEMAGNE  (1978) (Revue)

Mots-clés anglais / English Keywords

Mesenchymal cell

;

Cyclin dependent kinase inhibitor

;

Homeostasis

;

Progenitor cell

;

Stem cell

;

Hematopoietic cell

;

Review

;

Oxidative stress

;

Age

;

Ageing

;

Senescence

;

In vitro

;

Bone marrow

;

Mots-clés français / French Keywords

Cellule mésenchymateuse

;

Inhibiteur des kinases dépendantes des cyclines

;

Homéostasie

;

Cellule progéniteur

;

Cellule souche

;

Cellule hématopoïétique

;

Article synthèse

;

Stress oxydatif

;

Age

;

Vieillissement

;

Sénescence

;

In vitro

;

Moelle osseuse

;

Mots-clés espagnols / Spanish Keywords

Inhibidor cyclin dependent kinase

;

Homeostasis

;

Célula progenitor

;

Célula primitiva

;

Célula hematopoyética

;

Artículo síntesis

;

Estrés oxidativo

;

Edad

;

Envejecimiento

;

Senescencia

;

In vitro

;

Médula ósea

;

Mots-clés d'auteur / Author Keywords

Senescence

;

Aging

;

Bone marrow-derived cells, Oxidative stress

;

Cyclin-dependent kinase inhibitor

;

Localisation / Location

INIST-CNRS, Cote INIST : 21230, 35400015005565.0040

Nº notice refdoc (ud4) : 19014131



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