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Titre du document / Document title

Bloodstream infections in febrile neutropenic patients at a tertiary care center in Lebanon : a view of the past decade

Auteur(s) / Author(s)

KANAFANIA Zeina A. (1) ; DAKDOUKI Ghenwa K. (2) ; EL-CHAMMAS Khalil I. (3) ; EID Shaker (4) ; ARAJ George F. (5) ; KANJ Souha S. (6) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Division of Infectious Diseases, Duke University Medical Center, Durham, NC, ETATS-UNIS
(2) Hammoud Hospital, Sidon, LIBAN
(3) Department of Pediatrics, American University of Beirut Medical Center, Beirut, LIBAN
(4) Department of Internal Medicine, American University of Beirut Medical Center, Beirut, LIBAN
(5) Department of Pathology & Laboratory Medicine, American University of Beirut Medical Center, Beirut, LIBAN
(6) Division of Infectious Diseases, American University of Beirut Medical Center, Cairo Street, PO Box 113-6044, Hamra 110, 32090, Beirut, LIBAN

Résumé / Abstract

Objectives: Previous studies from Lebanon have shown Gram-negative organisms to be the predominant agents in febrile neutropenic patients. The objective of this study was to evaluate the most current epidemiological trends among patients with neutropenic fever. Methods: This prospective observational cohort study, the largest to date in the country, was conducted at the American University of Beirut Medical Center between January 2001 and December 2003, with the objective of describing the characteristics of patients with neutropenic fever and to assess temporal trends. Results: We included 177 episodes of neutropenic fever. The most common underlying malignancy was lymphoma (42.4%). Gastrointestinal and abdominal infections were predominant (31.6%) and 23.7% of cases represented fever of unknown origin. Gram-negative organisms were responsible for 78.8% (26/33) of bloodstream infections compared to 33.3% (11/33) with Gram-positive organisms. The in-hospital mortality rate in this study (12.1%) was considerably lower than in previous years. Conclusions: Gram-negative organisms are persistently predominant in our center. In a developing country like Lebanon with limited resources, lower mortality rates commensurate with worldwide reports were successfully achieved in this high-risk patient population. Protocols and guidelines should be adapted to the characteristics of individual institutions to ensure delivery of appropriate care to febrile neutropenic patients.

Revue / Journal Title

International journal of infectious diseases    ISSN  1201-9712 

Source / Source

2007, vol. 11, no5, pp. 450-453 [4 page(s) (article)] (22 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1996) (Revue)

Mots-clés anglais / English Keywords

Intestinal disease

;

Gastric disease

;

Digestive diseases

;

Lymphoproliferative syndrome

;

Malignant hemopathy

;

Leukopenia

;

Hemopathy

;

Asia

;

Infection

;

Bacteriosis

;

Abdomen

;

Gastroenteritis

;

Lymphoma

;

Malignant tumor

;

Gram negative bacteria

;

Human

;

Epidemiology

;

Lebanon

;

Fever

;

Neutropenia

;

Bacteremia

;

Mots-clés français / French Keywords

Intestin pathologie

;

Estomac pathologie

;

Appareil digestif pathologie

;

Lymphoprolifératif syndrome

;

Hémopathie maligne

;

Leucopénie

;

Hémopathie

;

Asie

;

Infection

;

Bactériose

;

Abdomen

;

Gastroentérite

;

Lymphome

;

Tumeur maligne

;

Bactérie Gram négatif

;

Homme

;

Epidémiologie

;

Liban

;

Fièvre

;

Neutropénie

;

Bactériémie

;

Mots-clés espagnols / Spanish Keywords

Intestino patología

;

Estómago patología

;

Aparato digestivo patología

;

Linfoproliferativo síndrome

;

Hemopatía maligna

;

Leucopenia

;

Hemopatía

;

Asia

;

Infección

;

Bacteriosis

;

Abdomen

;

Gastroenteritis

;

Linfoma

;

Tumor maligno

;

Bacteria Gram negativa

;

Hombre

;

Epidemiología

;

Líbano

;

Fiebre

;

Neutropenia

;

Bacteriemia

;

Mots-clés d'auteur / Author Keywords

Neutropenic fever

;

Bacteremia

;

Gram-negative infection

;

Lebanon

;

Localisation / Location

INIST-CNRS, Cote INIST : 26659, 35400016156649.0120

Nº notice refdoc (ud4) : 19005340



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