Titre du document / Document title

Epidermolysis bullosa acquisita associated with psoriasis vulgaris

Auteur(s) / Author(s)

HOSHINA D. ⁽¹⁾ ; SAWAMURA D. ⁽¹⁾ ; NOMURA T. ⁽¹⁾ ; TANIMURA S. ⁽¹⁾ ; ABE M. ⁽¹⁾ ; ONOZUKA T. ⁽¹⁾ ; KODAMA K. ⁽¹⁾ ; AKIYAMA M. ⁽¹⁾ ; SHIMIZU H. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, JAPON

Résumé / Abstract

We report a case of epidermolysis bullosa acquisita (EBA) associated with psoriasis vulgaris. A 71-year-old woman with psoriasis vulgaris developed subepidermal blisters on the extremities. Direct immunofluorescence demonstrated linear deposit of IgG at the basement membrane zone, which bound to the dermal side of normal human skin split with 1 mol/L NaCl. Immunoblot analysis using recombinant full-length type VII collagen detected a 290-kDa band, confirming the diagnosis of EBA. A literature search for previous reports found a few cases of EBA associated with psoriasis, and all cases, including our own, presented with widespread inflammatory vesicles and bullae, and responded to conventional therapy with corticosteroids and immunosuppressive agents. This study suggests that western blotting using recombinant full-length type VII collagen could be useful for diagnosis of EBA, and that EBA associated with psoriasis may have a tendency to be the inflammatory type.

Revue / Journal Title

Clinical and experimental dermatology   ISSN 0307-6938   CODEN CEDEDE 

Source / Source

2007, vol. 32, n^o5, pp. 516-518 [3 page(s) (article)] (10 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1976) (Revue)

Mots-clés anglais / English Keywords

Immunopathology ; Skin disease ; Autoimmune disease ; Bullous dermatosis ; Dermatology ; Association ; Psoriasis ; Epidermolysis bullosa ;

Mots-clés français / French Keywords

Immunopathologie ; Peau pathologie ; Maladie autoimmune ; Dermatose bulleuse ; Dermatologie ; Association ; Psoriasis ; Epidermolyse bulleuse ;

Mots-clés espagnols / Spanish Keywords

Inmunopatología ; Piel patología ; Enfermedad autoinmune ; Dermatosis bulosa ; Dermatología ; Asociación ; Psoriasis ; Epidermólisis bulosa ;

Localisation / Location

INIST-CNRS, Cote INIST : 16224, 35400015004188.0090