Titre du document / Document title

Dietary intake of fatty acids and serum C-reactive protein in Japanese

Auteur(s) / Author(s)

YONEYAMA Satoko ; MIURA Katsuyuki ; SASAKI Satoshi ; YOSHITA Katsushi ; MORIKAWA Yuko ; ISHIZAKI Masao ; KIDO Teruhiko ; NARUSE Yuchi ; NAKAGAWA Hideaki ;

Résumé / Abstract

BACKGROUND: Inflammation has been established as a risk factor for cardiovascular diseases. The relationships of polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids to inflammation are still controversial in Western populations. The relationships are not clear in Japanese whose intake of seafood-based long-chain n-3 PUFAs is high. METHODS: We conducted a cross-sectional epidemiologic study in the Japanese population (1,556 men and 1,461 women aged 35-60). Serum high sensitivity C-reactive protein (CRP) was measured, and intakes of 7 specific fatty acids (% of energy) were evaluated by a validated self-administered dietary history questionnaire. RESULTS: CRP was significantly and inversely related to the intakes of oleic acid (p=0.008) and α-linolenic acid (p=0.026) in women after adjustment for confounding factors. A multiple regression analysis showed that, especially in the middle fertile of long-chain n-3 PUFAs (eicosapentaenoic acid and docosahexaenoic acid) intake, CRP was inversely related to the intake of oleic acid and linoleic acid in both sexes and to the intake of α-linolenic acid in women. CONCLUSION: Intakes of oleic acid, linoleic acid, and α-linolenic acid would reduce serum CRP, especially when the intake of long-chain n-3 PUFAs is at a moderate level in Japanese.

Revue / Journal Title

Journal of epidemiology   ISSN 0917-5040 

Source / Source

2007, vol. 17, n^o3, pp. 86-92 [7 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Japan Epidemiological Association, Tokyo, JAPON  (1991) (Revue)

Mots-clés d'auteur / Author Keywords

C-Reactive Protein ; Fatty Acids ; Diet ; Epidemiology ;

Localisation / Location

INIST-CNRS, Cote INIST : 27275, 35400014648092.0030