Titre du document / Document title

Contact with farm animals in early life and juvenile inflammatory bowel disease : A case-control study

Auteur(s) / Author(s)

Chronische Autoimmunerkrankungen und Kontakt zu Tieren (Chronic Autoimmune Disease and Animal Contact) Study Group, ALLEMAGNE
RADON Katja ⁽¹⁾ ; WINDSTETTER Doris ^{(1 2)} ; POLUDA Anna Laura ⁽¹⁾ ; MUELLER Beatrice ⁽¹⁾ ; VON MUTIUS Erika ⁽²⁾ ; KOLETZKO Sibylle ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Institute and Outpatient Clinic for Occupational and Environmental Medicine, ALLEMAGNE
⁽²⁾ University Children's Hospital, Ludwig-Maximilians-University Munich, Munich, ALLEMAGNE

Résumé / Abstract

OBJECTIVE. The aim of this study was to test the association between farm animal contact in infancy and the development of juvenile Crohn disease and ulcerative colitis. METHODS. A case-control study was conducted in 13 children's hospitals by using a mailed questionnaire. Case subjects with Crohn disease or ulcerative colitis who were registered in these hospitals were eligible (response rate: 90%). Children who underwent strabismus surgery at 11 of the 13 centers served as control subjects (response rate: 85%). All children 6 to 18 years of age who were born in Germany without malformations were included (444 case subjects with Crohn disease, 304 case subjects with ulcerative colitis, and 1481 control subjects). RESULTS. Regular contact with farm animals during the first year of life was associated inversely with Crohn disease and ulcerative colitis. In addition, regular contact with cats in infancy was linked inversely with case status. Allergic rhinitis was correlated significantly with Crohn disease but not with ulcerative colitis. CONCLUSION. Contact with farm environments in infancy might decrease the risk of juvenile Crohn disease and ulcerative colitis.

Revue / Journal Title

Pediatrics   ISSN 0031-4005   CODEN PEDIAU 

Source / Source

2007, vol. 120, n^o2, pp. 360-367 [8 page(s) (article)] (32 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Academy of Pediatrics, Elk Grove Village, IL, ETATS-UNIS  (1948) (Revue)

Mots-clés anglais / English Keywords

Immunopathology ; Inflammatory disease ; Intestinal disease ; Digestive diseases ; Human ; Pediatrics ; Public health ; Epidemiology ; Case control study ; Adolescent ; Child ; Allergy ; Early ; Animal ; Ulcerative colitis ; Farming ; Contact ; Crohn disease ;

Mots-clés français / French Keywords

Immunopathologie ; Maladie inflammatoire ; Intestin pathologie ; Appareil digestif pathologie ; Homme ; Pédiatrie ; Santé publique ; Epidémiologie ; Etude cas témoin ; Adolescent ; Enfant ; Allergie ; Précoce ; Animal ; Rectocolite ulcérohémorragique ; Exploitation agricole ; Contact ; Entérite Crohn ;

Mots-clés espagnols / Spanish Keywords

Inmunopatología ; Enfermedad inflamatoria ; Intestino patología ; Aparato digestivo patología ; Hombre ; Pediatría ; Salud pública ; Epidemiología ; Estudio caso control ; Adolescente ; Niño ; Alergia ; Precoz ; Animal ; Rectocolitis ulcerohemorrágica ; Explotación agrícola ; Contacto ; Enteritis Crohn ;

Mots-clés d'auteur / Author Keywords

Crohn disease ; ulcerative colitis ; allergy ; farm animals ;

Localisation / Location

INIST-CNRS, Cote INIST : 6967, 35400016146517.0130