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Titre du document / Document title

The new neurobiology of autism : Cortex, connectivity, and neuronal organization

Auteur(s) / Author(s)

MINSHEW Nancy J. (1) ; WILLIAMS Diane L. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, ETATS-UNIS
(2) Department of Speech-Language Pathology, Duquesne University, Pittsburgh, ETATS-UNIS

Résumé / Abstract

This review covers a fraction of the new research developments in autism but establishes the basic elements of the new neurobiologic understanding of autism. Autism is a polygenetic developmental neurobiologic disorder with multiorgan system involvement, though it predominantly involves central nervous system dysfunction. The evidence supports autism as a disorder of the association cortex, both its neurons and their projections. In particular, it is a disorder of connectivity, which appears, from current evidence, to primarily involve intrahemispheric connectivity. The focus of connectivity studies thus far has been on white matter, but alterations in functional magnetic resonance imaging activation suggest that intracortical connectivity is also likely to be disturbed. Furthermore, the disorder has a broad impact on cognitive and neurologic functioning. Deficits in high-functioning individuals occur in processing that places high demands on integration of information and coordination of multiple neural systems. Intact or enhanced abilities share a dependence on low information-processing demands and local neural connections. This multidomain model with shared characteristics predicts an underlying pathophysiologic mechanism that impacts the brain broadly, according to a common neurobiologic principle. The multiorgan system involvement and diversity of central nervous system findings suggest an epigenetic mechanism.

Revue / Journal Title

Archives of neurology    ISSN  0003-9942   CODEN ARNEAS 

Source / Source

2007, vol. 64, no7, pp. 947-952 [6 page(s) (article)] (30 ref.)

Langue / Language


Editeur / Publisher

American Medical Association, Chicago, IL, ETATS-UNIS  (1960-2012) (Revue)

Mots-clés anglais / English Keywords

Developmental disorder






Nervous system diseases


Mots-clés français / French Keywords

Trouble développement






Système nerveux pathologie


Mots-clés espagnols / Spanish Keywords

Trastorno desarrollo






Sistema nervioso patología


Localisation / Location

INIST-CNRS, Cote INIST : 2048 B, 35400016163561.0030

Nº notice refdoc (ud4) : 18930923

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