Titre du document / Document title

Oral methotrexate compared with injected methotrexate when used with misoprostol for abortion

Auteur(s) / Author(s)

WIEBE E. R. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Family Practice, University of British Columbia, CANADA

Résumé / Abstract

OBJECTIVE: This study was undertaken to compare oral to injected methotrexate with respect to effectiveness, side effects, and acceptability. STUDY DESIGN: One hundred women in an urban primary care practice were randomly assigned in phase 1 to receive 50 mg/m² methotrexate by either the oral or the injected route. In phase 2 another 87 women were allowed to choose between the oral and injected routes. In both phases and in all groups the methotrexate was followed 5 to 7 days later by misoprostol administered vaginally by the patient. The main outcome was the success rate (the number whose pregnancies aborted without surgery); other outcomes included side effects and acceptability. RESULTS: There were no differences in rates of success, side effects, or acceptability between groups receiving oral and injected methotrexate. Among the women in phase 2 the oral form was chosen by 57.5%. CONCLUSION: This study indicates that for medical abortions induced with methotrexate and misoprostol it is possible to offer both the oral and injected routes of methotrexate without sacrificing efficacy and that about half of the women offered a choice will choose the oral route.

Revue / Journal Title

American journal of obstetrics and gynecology   ISSN 0002-9378   CODEN AJOGAH 

Source / Source

1999, vol. 181, n^o1, pp. 149-152 (22 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Philadelphia, PA, ETATS-UNIS  (1920) (Revue)

Mots-clés anglais / English Keywords

Induced abortion ; Methotrexate ; Chemotherapy ; Treatment ; Treatment efficiency ; Toxicity ; Comparative study ; Route of administration ; Oral administration ; Intramuscular administration ; Misoprostol ; Combined treatment ; Canada ; Adult ; Female ; Prostaglandin derivatives ; North America ; America ; Human ;

Mots-clés français / French Keywords

Avortement provoqué ; Méthotrexate ; Chimiothérapie ; Traitement ; Efficacité traitement ; Toxicité ; Etude comparative ; Voie administration ; Voie orale ; Voie intramusculaire ; Misoprostol ; Traitement associé ; Canada ; Adulte ; Femelle ; Prostaglandine dérivé ; Amérique du Nord ; Amérique ; Homme ;

Mots-clés espagnols / Spanish Keywords

Aborto provocado ; Metotrexato ; Quimioterapia ; Tratamiento ; Eficacia tratamiento ; Toxicidad ; Estudio comparativo ; Vía administración ; Vía oral ; Vía intramuscular ; Misoprostol ; Tratamiento asociado ; Canada ; Adulto ; Hembra ; Prostaglandina derivado ; America del norte ; America ; Hombre ;

Localisation / Location

INIST-CNRS, Cote INIST : 3053, 35400008924210.0260