Titre du document / Document title

Carbohydrate metabolism changes in cystic fibrosis

Auteur(s) / Author(s)

DOMINGUEZ-GARCIA Angela ; QUINTEIRO-GONZALEZ Sofia ; PENA-QUINTANA Luis ; RAMOS-MACIAS Leticia ; QUINTANA-MARTEL Mercedes ; SAAVEDRA-SANTANA Pedro ;

Résumé / Abstract

Aims: To assess the prevalence of impaired glucose tolerance (ITG) and diabetes mellitus (DMRCF) in a group of patients with cystic fibrosis (CF). To study clinical status-related variables and to compare age with the evolution of their carbohydrate metabolism (CHM). Patients and Methods: Thirty patients with CF (1.5-26 years). Oral glucose tolerance test (OGTT) in 28 patients. Results: Three patients (10%) showed ITG and four DMRCF (13.3%). CF patients with impaired CHM (ICHM) were older (p = 0.006), and had longer times since diagnosis and first sputum colonization (p = 0.001, p <0.001). Homozygous 8F508 mutation was significant (p = 0.001). Insulin peak, area under the curve for insulin, insulin resistance, insulin sensitivity, and pancreatic beta-cell function were all significant. Conclusions: ICHM was present in 23.3%. Age, time since diagnosis of CF, first sputum colonization and homozygous 8F508 mutation were significantly associated. CHM in patients with CF is similar to that in the population without CF in the early years.

Revue / Journal Title

Journal of pediatric endocrinology & metabolism   ISSN 0334-018X 

Source / Source

2007, vol. 20, n^o5, pp. 621-632 [12 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Freund, Tel Aviv, ISRAEL  (1985) (Revue)

Mots-clés d'auteur / Author Keywords

cystic fibrosis ; genotype ; diabetes mellitus ; oral glucose tolerance test ; impaired glucose tolerance ; insulin resistance ; beta-cell function ;

Localisation / Location

INIST-CNRS, Cote INIST : 20997, 35400014992680.0090