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Titre du document / Document title

Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland

Auteur(s) / Author(s)

APELBERG Benjamin J. (1) ; GOLDMAN Lynn R. (2) ; CALAFAT Antonia M. (3) ; HERBSTMAN Julie B. (1) ; KUKLENYIK Zsuzsanna (3) ; HEIDLER Jochen (2) ; NEEDHAM Larry L. (3) ; HALDEN Rolf U. (2) ; WITTER Frank R. (4) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, ETATS-UNIS
(2) Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, ETATS-UNIS
(3) Division of Laboratory Sciences, National Center for Environmental Health , Centers for Disease Control and Prevention, Atlanta, Georgia 30341, ETATS-UNIS
(4) Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, ETATS-UNIS

Résumé / Abstract

Polyfluoroalkyl compounds (PFCs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), are ubiquitous, man-made chemicals. Human data suggest that in utero exposures to these chemicals occur and some evidence of developmental toxicity in animals exists. To assess the distribution and determinants of fetal exposure to PFCs, we analyzed cord serum samples from 299 singleton newborns delivered between 2004 and 2005 in Baltimore, MD for 10 PFCs by employing on-line solid-phase extraction coupled with reversed-phase high-performance liquid chromatography-tandem mass spectrometry. PFOS and PFOA were detected in 99 and 100% of umbilical cord sera, with geometric mean concentrations of 4.9 and 1.6 ng/mL, respectively. PFOS and PFOA concentrations were highly correlated (Pearson's r= 0.64 after natural log transformation, p < 0.01). Eight other PFCs were detected less frequently and at lower concentrations than PFOS and PFOA. Geometric mean concentrations of PFOS for Asians (6.0 ng/mL) and Blacks (5.1 ng/mL) were higher than those for Whites (4.2 ng/mL), while PFOA levels were more evenly distributed by race. Other maternal demographic and socioeconomic characteristics, including age, education, marital status, and living in the city limits were not significantly associated with cord concentrations. Our findings suggest that in utero exposure to PFOS and PFOA is ubiquitous in a population of babies born in Baltimore, MD.

Revue / Journal Title

Environmental science & technology    ISSN  0013-936X   CODEN ESTHAG 

Source / Source

2007, vol. 41, no11, pp. 3891-3897 [7 page(s) (article)] (52 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Chemical Society, Washington, DC, ETATS-UNIS  (1967) (Revue)

Mots-clés anglais / English Keywords

America

;

North America

;

United States

;

Public health

;

Epidemiology

;

In utero

;

Teratogen

;

Toxicity

;

Pregnancy

;

Exposure

;

Fluorine Organic compounds

;

Organic perhalocompound

;

Maryland

;

Fetus

;

Mots-clés français / French Keywords

Amérique

;

Amérique du Nord

;

Etats Unis

;

Santé publique

;

Epidémiologie

;

In utero

;

Tératogène

;

Toxicité

;

Gestation

;

Exposition

;

Fluor Composé organique

;

Composé organique perhalogéné

;

Maryland

;

Foetus

;

Mots-clés espagnols / Spanish Keywords

America

;

America del norte

;

Estados Unidos

;

Salud pública

;

Epidemiología

;

In útero

;

Teratogeno

;

Toxicidad

;

Gestación

;

Exposición

;

Fluor Compuesto orgánico

;

Compuesto orgánico perhalogenado

;

Maryland

;

Feto

;

Localisation / Location

INIST-CNRS, Cote INIST : 13615, 35400016282999.0140

Nº notice refdoc (ud4) : 18838696



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