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Titre du document / Document title

Thermal stability of paracetamol and its pre-formulates obtained by spray drying

Auteur(s) / Author(s)

MEDEIROS Antonileni F. D. (1) ; SANTOS Ana Flavia O. (1) ; DE SOUZA F. S. (2) ; PROCOPIO J. V. V. (2) ; PINTO Marcia Ferraz (2) ; MACEDO R. O. (1 2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Pharmaceutical Sciences Department, Federal University of Pernambuco - UFPE, Artur de Sá Avenue, Cidade Universitária Zipcode 740-521 Recife, PE, BRESIL
(2) Unified Laboratories of Medicine Development and Assay - LUDEM, Federal University of Paraíba-UFPB, Campus I Zipcode 58059-900 Joao Pessoa, PB, BRESIL

Résumé / Abstract

Stability of drugs and products has a great practical interest, which is facing to strict regulation. Thermal studies, besides the determination of the thermal properties of the investigated product allow the verification of possible interactions between the drug substances and excipients. The objective of this work was to obtain solid pre-formulates of paracetamol (PC) by spray drying (SPDR), as well as to investigate their thermal behavior. Dynamic and isotherm TG, conventional DSC and DSC-photovisual coupled methods were used to characterize the conventional and pre-formulated mixtures obtained by SPDR. The results of both DSC investigations showed slight alterations in melting temperatures, which suggests incompatibilities. The TG decomposition data of the mixtures evidenced that the dry process via SPDR leads to stability enhancement of the pre-formulated mixtures.

Revue / Journal Title

Journal of thermal analysis and calorimetry    ISSN  1388-6150 

Source / Source

Congrès
ESTAC : European Symposium on Thermal Analysis and Calorimetry No9, Cracow , POLOGNE (28/08/2006)
2007, vol. 88, no 2 (315 p.)  [Document : 6 p.] (10 ref.), pp. 377-382 [6 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Springer, Dordrecht, PAYS-BAS  (1998) (Revue)

Mots-clés anglais / English Keywords

Antimigrainous agent

;

Analgesic

;

Antipyretic

;

Differential scanning calorimetry

;

Solid form

;

Thermal analysis

;

Spray drying

;

Paracetamol

;

Thermal stability

;

Mots-clés français / French Keywords

Antimigraineux

;

Analgésique

;

Antipyrétique

;

Calorimétrie différentielle balayage

;

Forme solide

;

Analyse thermique

;

Séchage pulvérisation

;

Paracétamol

;

Stabilité thermique

;

Mots-clés espagnols / Spanish Keywords

Agente antimigrañoso

;

Analgésico

;

Antipirético

;

Análisis calorimétrico barrido exploración

;

Forma sólida

;

Análisis térmico

;

Secado pulverización

;

Paracetamol

;

Estabilidad térmica

;

Mots-clés d'auteur / Author Keywords

paracetamol

;

spray drying

;

thermal analysis

;

Localisation / Location

INIST-CNRS, Cote INIST : 6367, 35400014684535.0120

Nº notice refdoc (ud4) : 18821248



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