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Titre du document / Document title

Schmorl's nodes: Common, highly heritable, and related to lumbar disc disease

Auteur(s) / Author(s)

WILLIAMS F. M. K. (1) ; MANEK N. J. (2) ; SAMBROOK P. N. (3) ; SPECTOR T. D. (1) ; MACGREGOR A. J. (4) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Twin Research and Genetic Epidemiology Unit, King's College London, St. Thomas Campus, London , ROYAUME-UNI
(2) Mayo Clinic, Rochester, MN, ETATS-UNIS
(3) Royal North Shore Hospital, Lt. Leonard's,, New South Wales, AUSTRALIE
(4) University of East Anglia, Norwich, ROYAUME-UNI

Résumé / Abstract

Objective. Schmorl's nodes (SN) are common, but little is known of their relationship with degenerative change and back pain or genetic and environmental factors influencing their expression. We studied healthy female twin volunteers to determine the prevalence and clinical features associated with SN. Methods. Serial sagittal T1- and T2-weighted magnetic resonance images of the lower thoracic and lumbar spine were analyzed in 516 healthy female twins (150 monozygotic and 366 dizygotic). The images were scored for lumbar degenerative change. Presence of SN was noted at cranial and caudal vertebral levels T9 to L5. Data on physical activity and back pain were collected by questionnaire. Heritability of SN was calculated using variance components modeling. Results. SN were found in 30% of subjects. Of the 374 SN, 153 (41%) were in the lumbar spine and 221 (59%) were in the thoracic spine. SN heritability was >70%. There was a positive association between SN and lumbar disc disease (LDD). SN were more frequent in subjects with back pain (for ≥2 SN: odds ratio [OR] 2.68, 95% confidence interval [95% CI] 1.11-6.47, P = 0.03), but this was largely accounted for by the association of SN with LDD (OR 1.97, 95% CI 0.78-5.0, P = 0.15 adjusted for LDD). No independent association of SN with back pain was identified. Conclusion. SN are common in middle-aged women and are strongly genetically determined. They are associated with lumbar degenerative change, which is a risk factor for back pain, but are not themselves an independent risk factor for back pain.

Revue / Journal Title

Arthritis care and research    ISSN  0893-7524   CODEN ARCREG 

Source / Source

2007, vol. 57, no5, pp. 855-860 [6 page(s) (article)] (36 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Hoboken, NJ, ETATS-UNIS  (1988-2000) (Revue)

Mots-clés anglais / English Keywords

Medical imagery

;

Spine disease

;

Diseases of the osteoarticular system

;

Degenerative disease

;

Arthropathy

;

Dorsal spine

;

Pain

;

Rheumatology

;

Vertebra

;

Skull

;

Thorax

;

Osteoarthritis

;

Intervertebral disk

;

Lumbar spine

;

Nuclear magnetic resonance imaging

;

Low back pain

;

Dorsalgia

;

Rachialgia

;

Mots-clés français / French Keywords

Imagerie médicale

;

Rachis pathologie

;

Système ostéoarticulaire pathologie

;

Maladie dégénérative

;

Arthropathie

;

Rachis dorsal

;

Douleur

;

Rhumatologie

;

Vertèbre

;

Crâne

;

Thorax

;

Arthrose

;

Disque intervertébral

;

Rachis lombaire

;

Imagerie RMN

;

Lombalgie

;

Dorsalgie

;

Rachialgie

;

Mots-clés espagnols / Spanish Keywords

Imaginería médica

;

Raquis patología

;

Sistema osteoarticular patología

;

Enfermedad degenerativa

;

Artropatía

;

Raquis dorsal

;

Dolor

;

Reumatología

;

Vértebra

;

Cráneo

;

Tórax

;

Artrosis

;

Disco intervertebral

;

Raquis lumbar

;

Imaginería RMN

;

Lumbalgia

;

Dorsalgia

;

Raquialgia

;

Mots-clés d'auteur / Author Keywords

Schmorl's nodes

;

Lumbar disc disease

;

Heritable

;

Osteoarthritis

;

Spine

;

Localisation / Location

INIST-CNRS, Cote INIST : 21540, 35400016231384.0230

Nº notice refdoc (ud4) : 18803679



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