Titre du document / Document title
Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages
Auteur(s) / Author(s)
CHANG Z. Q. (1) ;
OH B. C. (2) ;
RHEE M. H. (1) ;
KIM J. C. (3) ;
LEE S. P. (4) ;
PARK S. C. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, COREE, REPUBLIQUE DE
(2) Microbial Genomics Laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejon 305-600, COREE, REPUBLIQUE DE
(3) College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, COREE, REPUBLIQUE DE
(4) The Center for Traditional Microorganism Resources, Keimyung University, Daegu 704-701, COREE, REPUBLIQUE DE
Résumé / Abstract
Polysaccharides isolated from Phellinus baumii (PBP) significantly enhanced both lipopolysaccharide (LPS)-induced B lymphocyte proliferation and concanavalin A (Con A)-induced T lymphocyte proliferation. However, PBP (12.5-100 μg ml
-1) significantly suppressed the LPS-induced nitric oxide (NO) production in RAW264.7 cells in a concentration-dependent manner. The maximal inhibition of PBP on NO production was 37.5% at 100 μg ml
-1. These results provide useful in vitro information to explain the immunostimulating activity and antiinflammatory activity of PBP.
Revue / Journal Title
World journal of microbiology & biotechnology
ISSN
0959-3993
Source / Source
2007, vol. 23, n
o5, pp. 723-727 [5 page(s) (article)] (1/2 p.)
Langue / Language
Anglais
Editeur / Publisher
Springer, Dordrecht, PAYS-BAS
(1990)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 21001, 35400014685250.0170
Nº notice refdoc (ud4) : 18786956
