Titre du document / Document title

Ketoacidosis at diagnosis of type 1 diabetes in children in Northern Finland : Temporal changes over 20 years

Auteur(s) / Author(s)

HEKKALA Anne ⁽¹⁾ ; KNIP Mikael ^{(2 3)} ; VEIJOLA Riitta ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Pediatrics, University of Oulu, Oulu University Hospital, Oulu, FINLANDE
⁽²⁾ Hospital for Children and Adolescents, University of Helsinki, Helsinki, FINLANDE
⁽³⁾ Department of Pediatrics, Tampere University Hospital, Tampere, FINLANDE

Résumé / Abstract

OBJECTIVE - To study the frequency of diabetic ketoacidosis (DKA) over a 20-year period among children diagnosed with type 1 diabetes in northern Finland. RESEARCH DESIGN AND METHODS - The study population comprised 585 patients (328 boys) diagnosed with type 1 diabetes aged < 15 years in the Department of Pediatrics, Oulu University Hospital, between 1 January 1982 and 31 December 2001. The data for clinical characteristics were collected retrospectively from the patients' case records. The earlier 10-year period (1982-1991) was compared with the later 10-year period (1992-2001). Two definitions for DKA were used: DKA(i) pH <7.30 or DKA(ii) pH <7.30 and/or bicarbonate <15 mmol/l. RESULTS - During the later 10-year period, children less often had DKA at diagnosis [DKA(i) 15.2 vs. 22.4%, P = 0.028, and DKA(ii) 18.9 vs. 29.5%, P = 0.003]. The proportion of young children aged <5 years at diagnosis increased over time, but the frequency of DKA also was lower in this age-group during 1992-2001 compared with the earlier 10-year period [DKA(i) 17.7 vs. 32.1%, P = 0.052, and DKA(ii) 20.3 vs. 42.6%, P = 0.005]. In children aged <2 years at diagnosis, the frequency of DKA remained high during 1992-2001 [DKA(i) 39.1% and DKA(ii) 47.8%]. CONCLUSIONS - The overall frequency of DKA in children with newly diagnosed type 1 diabetes decreased over a 20-year period in northern Finland. However, children aged <2 years are still at high risk for DKA at diagnosis.

Revue / Journal Title

Diabetes care   ISSN 0149-5992   CODEN DICAD2 

Source / Source

2007, vol. 30, n^o4, pp. 861-866 [6 page(s) (article)] (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Diabetes Association, Alexandria, VA, ETATS-UNIS  (1978) (Revue)

Mots-clés anglais / English Keywords

Immunopathology ; Autoimmune disease ; Endocrinopathy ; Metabolic disorder ; Acid base balance disorder ; Europe ; Human ; Public health ; Finland ; Type 1 diabetes ; Child ; Diagnosis ; Ketoacidosis ;

Mots-clés français / French Keywords

Immunopathologie ; Maladie autoimmune ; Endocrinopathie ; Trouble métabolisme ; Trouble équilibre acidobasique ; Europe ; Homme ; Santé publique ; Finlande ; Diabète type 1 ; Enfant ; Diagnostic ; Acidocétose ;

Mots-clés espagnols / Spanish Keywords

Inmunopatología ; Enfermedad autoinmune ; Endocrinopatía ; Trastorno metabolismo ; Trastorno equilibrio acidobásico ; Europa ; Hombre ; Salud pública ; Finlandia ; Diabetes de tipo 1 ; Niño ; Diagnóstico ; Cetoacidosis ;

Localisation / Location

INIST-CNRS, Cote INIST : 18054, 35400014351614.0160