Titre du document / Document title

Effect of anthocyanin-rich extract from black rice (Oryza sativa L. indica) on hyperlipidemia and insulin resistance in fructose-fed rats

Auteur(s) / Author(s)

HONGHUI GUO ⁽¹⁾ ; WENHUA LING ⁽¹⁾ ; QING WANG ⁽¹⁾ ; CHI LIU ⁽¹⁾ ; YAN HU ⁽¹⁾ ; MIN XIA ⁽¹⁾ ; XIANG FENG ⁽¹⁾ ; XIAODONG XIA ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, Guangzhou, Guangdong Province 510080, CHINE

Résumé / Abstract

This study was designed to evaluate the effect of an anthocyanin-rich extract from black rice on hyperlipidemia and insulin resistance in fructose-fed rats. Rats fed fructose diet for 4 weeks exhibited significantly higher plasma insulin levels and lower insulin sensitivity than the control rats fed AIN-93G diet. Dietary supplementation with the anthocyanin-rich extract (5 g/kg of high-fructose diet) prevented the development of fructose-induced insulin resistance. After fructose-induced insulin resistance had been established, 4-week treatment with the anthocyanin-rich extract (5 g/kg of high-fructose diet) or pioglitazone (270 mg/kg of high-fructose diet) ameliorated the glucose intolerance and hyperlipidemia, but the extract failed to reverse the fructose-induced hyperinsulinemia as pioglitazone did. In addition, rats supplemented by the extract exhibited lower oxidative stress than the fructose-fed controls, as indicated by the lower concentrations of plasma thiobarbituric acid reactive substances and blood oxidized glutathione. Overall, these results suggest that the anthocyanin-rich extract from black rice improves certain metabolic abnormalities associated with diets high in fructose.

Revue / Journal Title

Plant foods for human nutrition   ISSN 0921-9668 

Source / Source

2007, vol. 62, n^o1, pp. 1-6 [6 page(s) (article)] (28 ref.)

Langue / Language

Anglais
Revue : Neerlandais

Editeur / Publisher

Springer, Heidelberg, ALLEMAGNE  (1987) (Revue)

Mots-clés anglais / English Keywords

Polyphenol ; Carbohydrate ; Feeding ; Cereal ; Vertebrata ; Mammalia ; Rodentia ; Spermatophyta ; Angiospermae ; Monocotyledones ; Gramineae ; Pigments ; Glucose ; Development ; Supplementation ; Sensitivity ; Diet ; Design ; Flavonoid ; Rat ; Fructose ; Resistance ; Insulin ; Oryza sativa ; Rice ; Extract ; Anthocyanin ;

Mots-clés français / French Keywords

Polyphénol ; Glucide ; Alimentation ; Céréale ; Vertebrata ; Mammalia ; Rodentia ; Spermatophyta ; Angiospermae ; Monocotyledones ; Gramineae ; Pigment ; Glucose ; Développement ; Supplémentation ; Sensibilité ; Régime alimentaire ; Conception ; Flavonoïde ; Rat ; Fructose ; Résistance ; Insuline ; Oryza sativa ; Riz ; Extrait ; Anthocyane ;

Mots-clés espagnols / Spanish Keywords

Polifenol ; Glúcido ; Alimentación ; Cereal ; Vertebrata ; Mammalia ; Rodentia ; Spermatophyta ; Angiospermae ; Monocotyledones ; Gramineae ; Pigmento ; Glucosa ; Desarrollo ; Suplementación ; Sensibilidad ; Régimen alimentario ; Diseño ; Flavonoide ; Rata ; Fructosa ; Resistencia ; Insulina ; Oryza sativa ; Arroz ; Extracto ; Antocianina ;

Mots-clés d'auteur / Author Keywords

Anthocyanin ; Black rice ; Hyperlipidemia ; Insulin resistance ; Metabolic syndrome ; Oxidative stress ;

Localisation / Location

INIST-CNRS, Cote INIST : 7104, 35400014719562.0010