Titre du document / Document title

Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia

Auteur(s) / Author(s)

KOPECEK Miloslav ; BARES Martin ; HORACEK Jiri ; MOHR Pavel ;

Résumé / Abstract

OBJECTIVE: Risperidone in antipsychotic doses induces hyperprolactinemia. The aim of this study was to verify whether the same is true for low doses of risperidone (0.5-2 mg per day) added to antidepressants or anxiolytics. METHODS: Prolactin levels were measured in 4 men (mean age 49.5±19.1 years) and 8 women (mean age 31.3±8.2 years) inpatients with depressive and anxiety disorders who were treated with risperidone (median doses per day 1.25 mg) for median 15.5 days as an augmentation treatment to antidepressants (n=8), anxiolytics (n=6) and mood stabilizers (n=2). RESULTS: 11 of 12 patients had hyperprolactinemia. Median plasma prolactin level was 1598mIU/ml, 95% CI 1 040-2661 mIU/ml. Significant correlation between risperidone daily dose and plasma prolactin level (Spearman's R=0.655, p=0.02) was detected. Two women suffered from galactorrhea and one from amenorrhea. CONCLUSIONS: Even low doses of risperidone used as an augmentation to antidepressants or benzodiazepines are associated with hyperprolactinemia and can induce endocrinological side effects. The co-medication of antidepressants and benzodiazepines can potentially increase intensity of prolactinemia.

Revue / Journal Title

Neuro endocrinology letters   ISSN 0172-780X   CODEN NLETDU 

Source / Source

2006, vol. 27, n^o6, pp. 803-806 [4 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Maghira & Maas, Stockholm, SUEDE  (1979) (Revue)

Mots-clés d'auteur / Author Keywords

risperidone ; prolactinemia ; depression ; anxiety ; side effect ; endocrinology ;

Localisation / Location

INIST-CNRS, Cote INIST : 18210, 35400014719133.0220