Titre du document / Document title

The effects of trazodone on sleep disturbances induced by brofaromine

Auteur(s) / Author(s)

HAFFMANS P. M. J. ⁽¹⁾ ; VOS M. S. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Stichting RBC, location Monsterseweg, Monsterseweg 83, 2553 the Hague, PAYS-BAS

Résumé / Abstract

The effects of trazodone on subjective and objective sleep parameters were compared to those of placebo in a double-blind design in seven patients who developed insomnia during treatment with the selective and reversible MAO-A inhibitor, brofaromine. Trazodone significantly increased deep sleep and altered the architecture of sleep in these patients. Subjectively, patients reported a better and deeper sleep. No negative interactions between brofaromine and trazodone were observed and side-effects were minimal. A low dose of trazodone may be a safe and effective agent in the treatment of MAO-I induced insomnia.

Revue / Journal Title

European psychiatry   ISSN 0924-9338 

Source / Source

1999, vol. 14, n^o3, pp. 167-171 (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Paris, FRANCE  (1991) (Revue)

Mots-clés anglais / English Keywords

Brofaromine ; MAO A inhibitor ; Antidepressant agent ; Toxicity ; Insomnia ; Chemotherapy ; Treatment ; Trazodone ; Hypnotic ; Psychotropic ; Human ; Sleep disorder ;

Mots-clés français / French Keywords

Brofaromine ; IMAO A ; Antidépresseur ; Toxicité ; Insomnie ; Chimiothérapie ; Traitement ; Trazodone ; Hypnotique ; Psychotrope ; Homme ; Trouble sommeil ;

Mots-clés espagnols / Spanish Keywords

Brofaromina ; IMAO A ; Antidepresor ; Toxicidad ; Insomnio ; Quimioterapia ; Tratamiento ; Trazodona ; Hipnótico ; Psicotropo ; Hombre ; Trastorno sueño ;

Localisation / Location

INIST-CNRS, Cote INIST : 21224, 35400008532591.0080