Titre du document / Document title

Interleukin-1 receptor antagonist (IL-1RN) and interleukin-lB gene polymorphisms in Turkish patients with rheumatoid arthritis

Auteur(s) / Author(s)

ARMAN A. ⁽¹⁾ ; YILMAZ B. ⁽²⁾ ; COKER A. ⁽³⁾ ; INANC N. ⁽²⁾ ; DIRESKENELI H. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Faculty of Engineering, Marmara University, Istanbul, TURQUIE
⁽²⁾ Department of Rheumatology, School of Medicine, Marmara University, Istanbul, TURQUIE
⁽³⁾ Department of Biology, Art and Sciences, Marmara University, Istanbul, TURQUIE

Résumé / Abstract

Objective Interleukin I (1L-1) family is composed of two agonists, 1L- 1α and 1L-1β and 1L-1 receptor antagonist, 1L-1Ra. The purpose of this study was to determine the relationship between polymorphisms of 1L- 1 receptor antagonist (IL-JRN), IL-1B promoter and 1L-1B exon 5 genes and susceptibility to rheumatoid arthritis (RA) in Turkish population. Methods Polymerase chain reaction (PCR) was used to determine the genotype of the ΙL-1RN for 94 RA patients and 104 healthy controls. Genotyping of IL-1 B polymorphisms at positions -511 (C/T) and +3953 (C/T) was detected by PCR followed restriction fragment length analysis. Results There was no significant difference in IL-1RN genotype and allele distributions between RA and the control groups. In addition, no significant association was observed in the allelic frequency (C or T) of IL-1B promoter (-511) between RA patients and the controls (P = 0,118), but the genotype distribution of 1/2 (C/T) at position -511 showed a significant difference (P = 0,038). Also, 2/2 genotype (T/T); (P = 0,028), and allele 2 (T) distribution (P 0,011) of IL-1B (+3953) showed significant differences between RA patients and the control groups in the study population. Conclusion These results imply that 2/2 (T/T) genotype or allele 2 (T) ofIL-B (+3953) are susceptibility factors for RA in Turkey. Also, 1/2 genotype (C/T) of 1L-1 -511 can play a protective role for RA.

Revue / Journal Title

Clinical and experimental rheumatology   ISSN 0392-856X 

Source / Source

2006, vol. 24, n^o6, pp. 643-648 [6 page(s) (article)] (43 ref.)

Langue / Language

Anglais

Editeur / Publisher

Clinical and Experimental Rheumatology, Pisa, ITALIE  (1983) (Revue)

Mots-clés anglais / English Keywords

Immunopathology ; Diseases of the osteoarticular system ; Inflammatory joint disease ; Autoimmune disease ; Chronic ; Human ; Polymorphism ; Antagonist ; Interleukin 1 ; Rheumatoid arthritis ;

Mots-clés français / French Keywords

Immunopathologie ; Système ostéoarticulaire pathologie ; Rhumatisme inflammatoire ; Maladie autoimmune ; Chronique ; Homme ; Polymorphisme ; Antagoniste ; Interleukine 1 ; Polyarthrite rhumatoïde ;

Mots-clés espagnols / Spanish Keywords

Inmunopatología ; Sistema osteoarticular patología ; Reumatismo inflamatorio ; Enfermedad autoinmune ; Crónico ; Hombre ; Polimorfismo ; Antagonista ; Interleuquina 1 ; Poliartritis reumatoidea ;

Mots-clés d'auteur / Author Keywords

IL-1B and IL-1RN polymorphism ; rheumatoid arthritis ;

Localisation / Location

INIST-CNRS, Cote INIST : 20920, 35400015975254.0050