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Titre du document / Document title

Adiposity compared with physical inactivity and risk of type 2 diabetes in women

Auteur(s) / Author(s)

RANA Jamal S. (1) ; LI Tricia Y. (2 3) ; MANSON Joann E. (3 4 5) ; HU Frank B. (2 3 4) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, ETATS-UNIS
(2) Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, ETATS-UNIS
(3) Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, ETATS-UNIS
(4) Channing Laboratory, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, ETATS-UNIS
(5) Division of Preventive Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, ETATS-UNIS

Résumé / Abstract

OBJECTIVE - The relative contribution of adiposity and physical inactivity to the risk of developing type 2 diabetes remains controversial. RESEARCH DESIGN AND METHODS - We prospectively examined the individual and joint association of obesity and physical activity with the development of type 2 diabetes in 68,907 female nurses who had no history of diabetes, cardiovascular disease, or cancer at baseline. Adiposity was measured by BMI and waist circumference. Physical activity was assessed through average hours of moderate or vigorous exercise and computation of an MET score. RESULTS- We documented 4,030 incident cases of type 2 diabetes during 16 years of follow-up (from 1986 to 2002). In a multivariate model including age, smoking, and other diabetes risk factors, risk of type 2 diabetes increased progressively with increasing BMI (P < 0.001) and waist circumference (P < 0.001) and with decreasing physical activity levels (P < 0.001). In joint analyses of BMI and physical activity, using women who had a healthy weight (BMI <25 kg/m2) and were physically active (exercise ≥21.8 MET h/week) as the reference group, the relative risks of type 2 diabetes were 16.75 (95% CI 13.99-20.04) for women who were obese (BMI ≥30 kg/m2) and inactive (exercise <2.1 MET h/week),10.74(8.74-13.18) for women who were active but obese, and 2.08 (1.66 -2.61) for women who were lean but inactive. In combined analyses of waist circumference and physical activity, both variables were significant predictors of type 2 diabetes, but the association for waist circumference was substantially stronger than that for physical inactivity. CONCLUSIONS - Obesity and physical inactivity independently contribute to the development of type 2 diabetes; however, the magnitude of risk contributed by obesity is much greater than that imparted by lack of physical activity.

Revue / Journal Title

Diabetes care    ISSN  0149-5992   CODEN DICAD2 

Source / Source

2007, vol. 30, no1, pp. 53-58 [6 page(s) (article)] (33 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Diabetes Association, Alexandria, VA, ETATS-UNIS  (1978) (Revue)

Mots-clés anglais / English Keywords

Nutrition disorder

;

Metabolic diseases

;

Endocrinopathy

;

America

;

North America

;

Nutritional status

;

United States

;

Public health

;

Physical exercise

;

Woman

;

Adult

;

Female

;

Human

;

Epidemiology

;

Risk factor

;

Obesity

;

Comparative study

;

Adipose tissue

;

Type 2 diabetes

;

Mots-clés français / French Keywords

Trouble nutrition

;

Métabolisme pathologie

;

Endocrinopathie

;

Amérique

;

Amérique du Nord

;

Etat nutritionnel

;

Etats Unis

;

Santé publique

;

Exercice physique

;

Femme

;

Adulte

;

Femelle

;

Homme

;

Epidémiologie

;

Facteur risque

;

Obésité

;

Etude comparative

;

Tissu adipeux

;

Diabète type 2

;

Mots-clés espagnols / Spanish Keywords

Trastorno nutricíon

;

Metabolismo patología

;

Endocrinopatía

;

America

;

America del norte

;

Estado nutricional

;

Estados Unidos

;

Salud pública

;

Ejercicio físico

;

Mujer

;

Adulto

;

Hembra

;

Hombre

;

Epidemiología

;

Factor riesgo

;

Obesidad

;

Estudio comparativo

;

Tejido adiposo

;

Diabetes de tipo 2

;

Localisation / Location

INIST-CNRS, Cote INIST : 18054, 35400014531421.0110

Nº notice refdoc (ud4) : 18439512



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