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Titre du document / Document title

Modulation of the infant immune responses by the first pertussis vaccine administrations

Auteur(s) / Author(s)

MASCART F. (1) ; HAINAUT M. (2) ; PELTIER A. (2) ; VERSCHEURE V. (1) ; LEVY J. (2) ; LOCHT C. (3 4) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Laboratory of Vaccinology and Mucosal Immunity, Erasme Hosp, Route de Lennik, 1070 Brussels, BELGIQUE
(2) Department of Pediatrics, Saint-Pierre Hosp, Rue Haute, 1000 Brussels, BELGIQUE
(3) INSERM U629, Lille, FRANCE
(4) Institut Pasteur de Lille, I, rue du Prof. Calmette, 59019 Lille, FRANCE

Résumé / Abstract

Many efforts are currently made to prepare combined vaccines against most infectious pathogens, that may be administered early in life to protect infants against infectious diseases as early as possible. However, little is known about the general immune modulation induced by early vaccination. Here, we have analyzed the cytokine secretion profiles of two groups of 6-month-old infants having received as primary immunization either a whole-cell (Pw) or an acellular (Pa) pertussis vaccine in a tetravalent formulation of pertussis-tetanus-diphtheria-poliomyelitis vaccines. Both groups of infants secreted IFN-γ in response to the Bordetella pertussis antigens filamentous haemagglutinin and pertussis toxin, and this response was correlated with antigen-specific IL-12p70 secretion, indicating that both pertussis vaccines induced Th1 cytokines. However, Pa recipients also developed a strong Th2-type cytokine response to the B. pertussis antigens, as noted previously. In addition, they induced Th2-type cytokines to the co-administrated antigen tetanus toxoïd, as well as to the food antigen beta-lactoglobulin. Furthermore, the general cytokine profile of the Pa recipients was strongly Th2-skewed at 6 months, as indicated by the cytokines induced by the mitogen phytohaemagglutinin. These data demonstrate that the cytokine profile of 6-month-old infants is influenced by the type of formulation of the pertussis vaccine they received at 2, 3 and 4 months of life. Large prospective studies would be warranted to evaluate the possible long-term consequences of this early modulation of the cytokine responses in infants.

Revue / Journal Title

Vaccine    ISSN  0264-410X   CODEN VACCDE 

Source / Source

2007, vol. 25, no2, pp. 391-398 [8 page(s) (article)] (31 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1983) (Revue)

Mots-clés anglais / English Keywords

Helper cell

;

Infection

;

Bacteriosis

;

Respiratory disease

;

Whooping cough

;

Th2 lymphocyte

;

T-Lymphocyte

;

Vaccine

;

Immune response

;

Infant

;

Human

;

Mots-clés français / French Keywords

Cellule helper

;

Infection

;

Bactériose

;

Appareil respiratoire pathologie

;

Coqueluche

;

Lymphocyte Th2

;

Lymphocyte T

;

Vaccin

;

Réponse immune

;

Nourrisson

;

Homme

;

Mots-clés espagnols / Spanish Keywords

Célula auxiliar

;

Infección

;

Bacteriosis

;

Aparato respiratorio patología

;

Tos ferina

;

Linfocito Th2

;

Linfocito T

;

Vacuna

;

Respuesta inmune

;

Lactante

;

Hombre

;

Mots-clés d'auteur / Author Keywords

Human infants

;

Pertussis vaccines

;

Thl/Th2 cells

;

Localisation / Location

INIST-CNRS, Cote INIST : 20289, 35400014529102.0200

Nº notice refdoc (ud4) : 18422664



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