Titre du document / Document title

Clinical implications of Parkinson's disease genetics

Auteur(s) / Author(s)

LORINCZ Matthew T. ;

Résumé / Abstract

Parkinson's disease (PD) is a significant neurodegenerative disease of the elderly, affecting 1 to 2% of those over 60 years of age. The disorder is characterized by resting tremor, bradykinesia, rigidity, postural instability, and pathologically by α-synuclein-positive Lewy bodies. For most, the etiology is unknown and it is likely due to a multifactorial interaction of genes and the environment. In a minority, a clear environmental, toxic, or genetic etiology is determined. Six genes have been identified to cause diseases often indistinguishable from sporadic PD. Although accounting for only 1 to 3% ofPD, the identification of single genes that cause PD clearly indicate that PD can have solely genetic causes. In addition to single-gene mutations, large familial aggregation and twin studies demonstrate a modest genetic component in idiopathic PD.

Revue / Journal Title

Seminars in neurology   ISSN 0271-8235   CODEN SEMNEP 

Source / Source

2006, vol. 26, n^o5, pp. 492-498 [7 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Thieme, New York, NY, ETATS-UNIS  (1981) (Revue)

Mots-clés d'auteur / Author Keywords

Parkinson's disease ; parkin ; α-synudein ; neurodegenerative disorders ; LRRK2 ;

Localisation / Location

INIST-CNRS, Cote INIST : 19739, 35400014525068.0030