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Titre du document / Document title

Immunomodulatory and anticancer activities of flavonoids extracted from litchi (Litchi chinensis Sonn.) pericarp

Auteur(s) / Author(s)

MOUMING ZHAO (1) ; BAO YANG (1) ; JINSHUI WANG (1) ; YANG LIU (1) ; LIMEI YU (1) ; YUEMING JIANG (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, CHINE
(2) South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, CHINE

Résumé / Abstract

The litchi pericarp extract was subjected to partition by hexane, ethyl acetate and water. Epicatechin, proanthocyanidin B2 and proanthocyanidin B4 were isolated and purified from the ethyl acetate fraction by reverse-phase high performance liquid chromatography. The immunomodulatory activities of epicatechin, proanthocyanidin B2, proanthocyanidin B4 and the ethyl acetate fraction were examined using proliferation of mouse splenocytes. The results showed all these samples had much higher stimulatory effects on splenocyte proliferation than that of the reference, rutin. Epicatechin and the ethyl acetate fraction showed a significantly (P<0.05) stimulatory effect when the concentration was up to 12.5 μg/ml. Proanthocyanidin B2 and proanthocyanidin B4 exhibited little lower stimulatory effects than epicatechin and the ethyl acetate fraction. The anti-breast cancer activities of epicatechin, proanthocyanidin B2, proanthocyanidin B4 and the ethyl acetate fraction were also evaluated. Epicatechin and proanthocyanidin B2 had lower cytotoxicities to human breast cancer cell MCF-7 and human embryolic lung fibroblast than paclitaxel.

Revue / Journal Title

International immunopharmacology    ISSN  1567-5769 

Source / Source

2007, vol. 7, no2, pp. 162-166 [5 page(s) (article)] (28 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (2001) (Revue)

Mots-clés anglais / English Keywords

Phenols

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Sapindaceae

;

Proanthocyanidin

;

Polyphenol

;

Litchi chinensis

;

Extract

;

Flavonoid

;

Biological activity

;

Antineoplastic agent

;

Immunomodulation

;

Immunomodulator

;

Mots-clés français / French Keywords

Phénols

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Sapindaceae

;

Proanthocyanidine

;

Polyphénol

;

Litchi chinensis

;

Extrait

;

Flavonoïde

;

Activité biologique

;

Anticancéreux

;

Immunomodulation

;

Immunomodulateur

;

Mots-clés espagnols / Spanish Keywords

Fenoles

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Sapindaceae

;

Proantocianidina

;

Polifenol

;

Litchi chinensis

;

Extracto

;

Flavonoide

;

Actividad biológica

;

Anticanceroso

;

Inmunomodulación

;

Inmunomodulador

;

Mots-clés d'auteur / Author Keywords

Litchi pericarp

;

Epicatechin

;

Proanthocyanidin B4

;

Proanthocyanidin B2

;

Immunomodulatory activity

;

Anticancer activity

;

Localisation / Location

INIST-CNRS, Cote INIST : 27109, 35400015967517.0060

Nº notice refdoc (ud4) : 18403041



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