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Titre du document / Document title

Fear conditioning and extinction : Influence of sex and menstrual cycle in healthy humans

Auteur(s) / Author(s)

MILAD Mohammed R. (1 2) ; GOLDSTEIN Jill M. (1 2 3) ; ORR Scott P. (1 2 4) ; WEDIG Michelle M. (1 2) ; KLIBANSKI Anne (2) ; PITMAN Roger K. (1 2) ; RAUCH Scott L. (1 2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Harvard Medical School, ETATS-UNIS
(2) Massachusetts General Hospital, ETATS-UNIS
(3) Brigham and Women's Hospital, ETATS-UNIS
(4) Veterans Affairs Medical Center, Manchester, New Hampshire, ETATS-UNIS

Résumé / Abstract

Although sex differences have been demonstrated in behavioral paradigms of fear conditioning, the findings have been inconsistent, and fear extinction has been little studied. The present study investigated the influence of sex and menstrual cycle phase on the recall of fear extinction. Three groups of healthy adult participants were studied: women at 2 different phases of the menstrual cycle (early follicular [early cycle] and late follicular [midcycle]) and men. Participants underwent a 2-day fear conditioning and extinction protocol. The paradigm entailed habituation, fear conditioning, and extinction learning on Day I and extinction recall and fear renewal on Day 2. Skin conductance served as the dependent variable. During fear acquisition on Day 1, men showed significantly larger conditioned responses relative to women; early cycle and midcycle women did not differ. No significant group differences were found during extinction learning. On Day 2, men and early cycle women expressed greater extinction memory than midcycle women. These data confirm sex differences in conditioned fear acquisition and suggest that midcycle hormones attenuate extinction recall.

Revue / Journal Title

Behavioral neuroscience    ISSN  0735-7044   CODEN BENEDJ 

Source / Source

2006, vol. 120, no6, pp. 1196-1203 [8 page(s) (article)] (1 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

American Psychological Association, Washington, DC, ETATS-UNIS  (1983) (Revue)

Mots-clés anglais / English Keywords

Sex steroid hormone

;

Ovarian hormone

;

Affect affectivity

;

Human

;

Skin

;

Electrical conductance

;

Electrodermography

;

Follicular phase

;

Anxiety

;

Estrogen

;

Memory

;

Acquisition process

;

Learning

;

Menstrual cycle

;

Sex

;

Extinction

;

Conditioning

;

Emotion emotionality

;

Fear

;

Mots-clés français / French Keywords

Hormone stéroïde sexuelle

;

Hormone ovarienne

;

Affect affectivité

;

Homme

;

Peau

;

Conductance électrique

;

Electrodermographie

;

Phase folliculaire

;

Angoisse anxiété

;

Oestrogène

;

Mémoire

;

Processus acquisition

;

Apprentissage

;

Cycle menstruel

;

Sexe

;

Extinction

;

Conditionnement

;

Emotion émotivité

;

Peur

;

Mots-clés espagnols / Spanish Keywords

Hormona esteroide sexual

;

Hormona ovárica

;

Afecto afectividad

;

Hombre

;

Piel

;

Conductancia eléctrica

;

Electrodermografía

;

Fase proliferativa

;

Angustia ansiedad

;

Estrógeno

;

Memoria

;

Proceso adquisición

;

Aprendizaje

;

Ciclo menstrual

;

Sexo

;

Extinción

;

Acondicionamiento

;

Emoción emotividad

;

Miedo

;

Mots-clés d'auteur / Author Keywords

learning and memory

;

estrogen

;

anxiety

;

follicular phase

;

skin conductance response

;

Localisation / Location

INIST-CNRS, Cote INIST : 2083 B, 35400014522669.0020

Nº notice refdoc (ud4) : 18393989



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