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Titre du document / Document title

Biological activity of isoquinoline alkaloids

Auteur(s) / Author(s)

CAPASSO Anna (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, ITALIE

Résumé / Abstract

Our interest has been centered on isoquinoline alkaloids (biologically derived from phenylalanine) from Argemone mexicana (Papaveraceae), Aristolochia constricta (Aristolochiaceae) and the opium alkaloid, papaverine. In this respect, the effect of isoquinoline alkaloids from A. mexicana and A. constricta was investigated on the naloxone-precipitated withdrawal contracture of the acute morphine-dependent guinea-pig ileum in vitro. Their activity was compared to the control compound, papaverine. Furthermore, the effect of these isoquinoline alkaloids was also considered on DAGO (highly selective μ-agonist) and U50-488H (highly selective k-agonist) withdrawal to test whether the possible interaction of isoquinoline alkaloids on opioid withdrawal involves μ-and/or k-opioid receptors. Isoquinoline alkaloids from A. mexicana (from 5×10-6 to 1×10-4 M), from A. constricta (1×10-5-5×10-5-1×10-4 M) as well as papaverine treatment (1×10-7-5×10-7-1×10-6 M) before or after the opioid agonists were able of both preventing and reversing the naloxone-induced contracture after exposure to μ (morphine and DAGO) or k (U50-488H) opiate agonists in a concentration-dependent manner. Both acetylcholine response and electrical stimulation were not affected by isoquinoline alkaloids and papaverine treatment whereas the final opiate withdrawal was still reduced. The results of the present study indicate that isoquinoline alkaloids as well as papaverine were able to produce significative influence on the opiate withdrawal in vitro and these compounds were able to exert their effects both at μ and k opioid agonists.

Source / Source

Recent research developments in biochemistry :   ( Volume 6 (2005). Part II )
2005  , pp. 1-12[Note(s) :  [173 p.]] [Document : 12 p.] (39 ref.), [Notes: Résumés en début de chapitres] ISBN 81-7736-297-6 ;  Illustration : Illustration ;

Langue / Language

Anglais

Editeur / Publisher

Research signpost, Trivandrum, INDE  (2005) (Monographie)

Mots-clés anglais / English Keywords

Isoquinoline derivatives

;

Alkaloid

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Aristolochiaceae

;

Papaverine

;

Papaveraceae

;

Biological activity

;

Mots-clés français / French Keywords

Isoquinoléine dérivé

;

Alcaloïde

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Aristolochia constricta

;

Argemone mexicana

;

Aristolochiaceae

;

Papavérine

;

Papaveraceae

;

Activité biologique

;

Mots-clés espagnols / Spanish Keywords

Isoquinoleína

;

Alcaloide

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Aristolochiaceae

;

Papaverina

;

Papaveraceae

;

Actividad biológica

;

Localisation / Location

INIST-CNRS, Cote INIST : L 30679, 35400015367890.0010

Nº notice refdoc (ud4) : 18315969



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