Titre du document / Document title
A-type proanthocyanidins from peanut skins
Auteur(s) / Author(s)
HONGXIANG LOU (1) ;
YAMAZAKI Y. (1) ;
SASAKI T. (2) ;
UCHIDA M. (2) ;
TANAKA H. (1) ;
OKA S. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) National Institute of Bioscience and Human Technology, Agency of Industrial Science and Technology, 1-1 Higashi, Tsukuba 305-8566, Ibaraki, JAPON
(2) Tokiwa Phytochemical Co. Ltd., Kinogo, Sakura 285-0801, Chiba, JAPON
Résumé / Abstract
Six A-type proanthocyanidins were isolated from the water-soluble fraction of peanut skins. On the basis of spectral data, reductive cleavage with sodium cyanoborohydride, and chiral HPLC analysis, three new compounds, epicatechin-(2β→O→7, 4β →6)-catechin, epicatechin-(2β→O→7, 4β→6)-ent-catechin and epicatechin-(2β→O→7, 4β→6)-ent-epicatechin were unambiguously identified, together with the three known compounds, proanthocyanidin A-1, proanthocyanidin A-2 and epicatechin-(2β→O→7, 4β→8)-ent-epicatechin.
13C NMR chemical shift rules to distinguish between [2→O→7, 4→8] and [2→O →7,4→6] double-linked heptamethyl ethers of A-type proanthocyanidins are proposed. Bioassay experiments showed that these six compounds possess substantial activity against hyaluronidase.
Revue / Journal Title
Phytochemistry
ISSN
0031-9422
Source / Source
1999, vol. 51, n
o2, pp. 297-308 (16 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Amsterdam, PAYS-BAS
(1961)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 9408, 35400008483456.0170
Nº notice refdoc (ud4) : 1831517
