Titre du document / Document title

Overcoming the challenges now limiting islet transplantation : A sequential, integrated approach

Auteur(s) / Author(s)

PILEGGI Antonello ; COBIANCHI Lorenzo ; INVERARDI Luca ; RICORDI Camillo ;

Résumé / Abstract

Steady improvements in islet cell processing technology and immunosuppressive protocols have made pancreatic islet transplantation a clinical reality for the treatment of patients with Type diabetes mellitus (T1DM). Recent trials are showing that improved glycemic metabolic control, prevention of severe hypoglycemia, and better quality of life can be reproducibly achieved after transplantation of allogeneic islets in patients with unstable Tl DM. Despite these encouraging results, challenges ahead comprise obtaining adequate islet cells for transplant, enhancing islets engraftment, sustaining β cell mass and function over time, and defining effective immune interventions, among others. In order to overcome the current hurdles to the widespread application of islet trans-plantation there is a need for implementation of integrated, sequential therapeutic approaches.

Revue / Journal Title

Annals of the New York Academy of Sciences   ISSN 0077-8923   CODEN ANYAA9 

Source / Source

2006, vol. 1079, pp. 383-398 [16 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Malden, MS, ETATS-UNIS  (1877) (Revue)

Mots-clés d'auteur / Author Keywords

diabetes ; islet transplantation ; β cell replacement ; insulin ; stem cells ; cytoprotection ; immune intervention ; immunosuppression ; tolerance ; bioengineering ; pancreas ;

Localisation / Location

INIST-CNRS, Cote INIST : 600, 35400015905210.0590