Titre du document / Document title

TEDDY-the environmental-determinants of diabetes in the young : An observational clinical trial

Auteur(s) / Author(s)

HAGOPIAN William A. ; LERNMARK Ake ; REWERS Marian J. ; SIMELL Olli G. ; SHE Jin-Xiong ; ZIEGLER Anette G. ; KRISCHER Jeffrey P. ; AKOLKAR Beena ;

Résumé / Abstract

The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.

Revue / Journal Title

Annals of the New York Academy of Sciences   ISSN 0077-8923   CODEN ANYAA9 

Source / Source

2006, vol. 1079, pp. 320-326 [7 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Malden, MS, ETATS-UNIS  (1877) (Revue)

Mots-clés d'auteur / Author Keywords

type 1 diabetes ; islet autoantibodies ; HLA ; virus ;

Localisation / Location

INIST-CNRS, Cote INIST : 600, 35400015905210.0490