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Titre du document / Document title

Anxiolytic-, antidepressant-and anticonvulsant-like effects of the alkaloid montanine isolated from Hippeastrum vittatum

Auteur(s) / Author(s)

FLAVIA SCHURMANN DA SILVA Ana (1) ; PAULO DE ANDRADE Jean (1) ; BEVILAQUA Lia R. M. (2 3) ; DE SOUZA Marcia Maria (4) ; IZQUIERDO Ivan (3) ; TERESINHA HENRIQUES Amélia (1) ; SILVEIRA ZUANAZZI José Angelo (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90, 610-000, Porto Alegre, RS, BRESIL
(2) Departamento de Bioquímica, ICBS, Universidade Fédéral do Rio Grande do Sul, Rua Ramiro Barcelos, 2.600, Anexo, 90035-003, Porto Alegre, RS, BRESIL
(3) Centro de Memória, Instituto de Pesquisas Biomédicas, Pontificia Universidade Católica do Rio Grande do Sul, Av. Ipiranga 6690, Andar 2, 90610-000, Porto Alegre, RS, BRESIL
(4) Faculdade de Farmácia, Universidade do Vale do Itajaí, Rua Uruguai, 88, 300-300, Itajaí, SC, BRESIL

Résumé / Abstract

Compounds isolated from different members of the Amaryllidaceae family are becoming relevant options for the treatment of neurological disorders and neurodegenerative diseases. In particular, species of the Hippeastrum genus are important source of alkaloids with a wide profile of putative therapeutical applications. Here, we report on the behavioral and pharmaco-toxicological characterization of montanine, an isoquinoline alkaloid isolated from Hippeastrum vittatum, an ornamental plant found throughout the world. In mice, montanine showed a LD50 of 64.7 mg/kg and 67.6 mg/kg for male and female, respectively. When given i.p., montanine dose-dependently decreased sodium pentobarbital-induced sleep, protected against pentylenetetrazole-provoked convulsions, increased the number of entries and the time spent in the open arms of an elevated plus maze and augmented the time spent struggling during a forced swimming test. When given immediately after inhibitory avoidance training, montanine did not affect avoidance memory retention in rats. Our results suggest that montanine, as other alkaloids isolated from Amaryllidaceae species, has psychopharmacological activities including anxiolytic, antidepressive and anticonvulsive effects.

Revue / Journal Title

Pharmacology, biochemistry and behavior    ISSN  0091-3057   CODEN PBBHAU 

Source / Source

2006, vol. 85, no1, pp. 148-154 [7 page(s) (article)] (1 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1973) (Revue)

Mots-clés anglais / English Keywords

Nervous system diseases

;

Neurological disorder

;

Mood disorder

;

Spermatophyta

;

Angiospermae

;

Monocotyledones

;

Amaryllidaceae

;

Convulsion

;

Depression

;

Memory

;

Anxiety

;

Hippeastrum

;

Alkaloid

;

Anticonvulsant

;

Psychotropic

;

Treatment

;

Chemotherapy

;

Antidepressant agent

;

Tranquillizer

;

Mots-clés français / French Keywords

Système nerveux pathologie

;

Trouble neurologique

;

Trouble humeur

;

Spermatophyta

;

Angiospermae

;

Monocotyledones

;

Amaryllidaceae

;

Convulsion

;

Etat dépressif

;

Mémoire

;

Angoisse anxiété

;

Hippeastrum

;

Alcaloïde

;

Anticonvulsivant

;

Psychotrope

;

Traitement

;

Chimiothérapie

;

Antidépresseur

;

Tranquillisant

;

Mots-clés espagnols / Spanish Keywords

Sistema nervioso patología

;

Trastorno neurológico

;

Trastorno humor

;

Spermatophyta

;

Angiospermae

;

Monocotyledones

;

Amaryllidaceae

;

Convulsión

;

Estado depresivo

;

Memoria

;

Angustia ansiedad

;

Hippeastrum

;

Alcaloide

;

Anticonvulsivante

;

Psicotropo

;

Tratamiento

;

Quimioterapia

;

Antidepresor

;

Tranquilizante

;

Mots-clés d'auteur / Author Keywords

Montanine

;

Alkaloid

;

Amaryllidaceae

;

Hippeastrum

;

Anxiety

;

Memory

;

Depression

;

Convulsion

;

Localisation / Location

INIST-CNRS, Cote INIST : 16578, 35400015904247.0190

Nº notice refdoc (ud4) : 18303063



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