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Titre du document / Document title

Differential effects of cocaine and ketamine on time estimation : Implications for neurobiological models of interval timing

Auteur(s) / Author(s)

CHENG Ruey-Kuang (1) ; MACDONALD Christopher J. (1) ; MECK Warren H. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Psychology and Neuroscience, Genome Sciences Research Building II -3rd Floor 572 Research Drive -Box 91050, Duke University, Durham, North Carolina 27708, ETATS-UNIS

Résumé / Abstract

The present experiment examined the effects of cocaine (0.0 and 15 mg/kg, i.p.) and ketamine (0.0, 10.0 and 15 mg/kg, i.p.) on timing behavior using a 12-s differential reinforcement of low rates (DRL) procedure and a 2- vs. 8-s bisection procedure in rats. DRL (time production) and bisection (time perception) procedures are sensitive to effects of dopaminergic drugs and provide an assessment of the accuracy and precision of interval timing as well as the subject's level of impulsivity. When administered to rats trained on either the DRL or the bisection procedure, cocaine shifted the psychophysical functions leftward relative to control conditions. In contrast, ketamine produced no change in the temporal control of behavior on either procedure. These differential effects of cocaine and ketamine are consistent with previous reports suggesting that dopamine levels in the dorsal striatum, but not in prefrontal cortex, ventral striatum or hippocampal regions, are crucial for the regulation of the speed of an internal clock.

Revue / Journal Title

Pharmacology, biochemistry and behavior    ISSN  0091-3057   CODEN PBBHAU 

Source / Source

2006, vol. 85, no1, pp. 114-122 [9 page(s) (article)] (2 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1973) (Revue)

Mots-clés anglais / English Keywords

Central nervous system

;

Basal ganglion

;

Encephalon

;

Excitatory aminoacid

;

Neurotransmitter

;

Catecholamine

;

NMDA receptor

;

Glutamate receptor

;

Antagonist

;

Ester

;

Drug of abuse

;

CNS stimulant

;

Psychotropic

;

Corpus striatum

;

NMDA

;

Glutamate

;

Dopamine

;

Timing

;

Models

;

Time perception

;

Ketamine

;

Cocaine

;

Mots-clés français / French Keywords

Phencyclidine dérivé

;

Système nerveux central

;

Noyau gris central

;

Encéphale

;

Aminoacide excitateur

;

Neurotransmetteur

;

Catécholamine

;

Récepteur NMDA

;

Récepteur glutamate

;

Antagoniste

;

Ester

;

Substance toxicomanogène

;

Stimulant SNC

;

Psychotrope

;

Corps strié

;

NMDA

;

Glutamate

;

Dopamine

;

Timing

;

Modèle

;

Perception temps

;

Kétamine

;

Cocaïne

;

Mots-clés espagnols / Spanish Keywords

Sistema nervioso central

;

Núcleo basal

;

Encéfalo

;

Aminoácido excitador

;

Neurotransmisor

;

Catecolamina

;

Receptor NMDA

;

Receptor glutámato

;

Antagonista

;

Ester

;

Sustancia toxicomanógena

;

Estimulante SNC

;

Psicotropo

;

Cuerpo estriado

;

NMDA

;

Glutamato

;

Dopamina

;

Timing

;

Modelo

;

Percepción tiempo

;

Ketamina

;

Cocaína

;

Mots-clés d'auteur / Author Keywords

Timing

;

Time perception

;

Dopamine

;

Glutamate

;

NMDA

;

Striatum

;

Cortex

;

Localisation / Location

INIST-CNRS, Cote INIST : 16578, 35400015904247.0150

Nº notice refdoc (ud4) : 18303059



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