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Titre du document / Document title

Oxidant stress and antioxidant status among patients with nonalcoholic fatty liver disease (?NAFLD)

Auteur(s) / Author(s)

MADAN Kaushal (1) ; BHARDWAJ Payal (1) ; THAREJA Sandeep (1) ; GUPTA Siddhartha D. (2) ; SARAYA Anoop (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Gastroenterology and Human nutrition, All India Institute of Medical Sciences, New Delhi, INDE
(2) Department of Pathology, All India Institute of Medical Sciences, New Delhi, INDE

Résumé / Abstract

Background: One of the major pathogenic mechanisms for progression of nonalcoholic fatty liver disease (NAFLD) is oxidative stress. Recently, many studies have demonstrated the role of oxidative stress in NAFLD however, studies describing the antioxidant status in these patients are lacking. Aim: To study the levels of oxidative stress and antioxidant status among patients with NAFLD. Patients and Methods: It was a prospective study in which 29 patients with NAFLD, 25 diseased controls with chronic viral hepatitis, and 23 healthy controls were enrolled. Apart from standard biochemical parameters, lipid peroxidation products were measured as thiobarbituric acid reactive substances. As measures of antioxidant capacity, superoxide dismutase, vitamin C levels and ferric reducing ability of plasma were measured. Results: Level of thiobarbituric acid reactive substances was significantly higher among NAFLD patients as compared with diseased [4.7nmol/mL (1.0 to 10.2) vs. 2.4nmol/mL (0.8 to 10.7); P = 0.02] or healthy controls [4.7nmol/mL (1.0 to 10.2) vs. 1.8nmol/mL (0.5 to 4.1); P = 0.0001]. FRAP was found to be significantly higher in patients with NAFLD as compared with healthy controls [450.3 (197.6 to 733.3) vs. 340.8 (141.6 to 697.5) μmol Fe2 liberated; P = 0.04], even though it was similar between NAFLD and diseased controls. Among NAFLD patients, there was no significant correlation between histological grading or staging and levels of pro and antioxidants. Conclusions: Products of lipid peroxidation are significantly increased among patients with NAFLD as compared with chronic viral hepatitis or healthy controls. Larger studies and newer markers of oxidative stress are required to clarify the association between oxidative stress and histological severity in NAFLD.

Revue / Journal Title

Journal of clinical gastroenterology    ISSN  0192-0790   CODEN JCGADC 

Source / Source

2006, vol. 40, no10, pp. 930-935 [6 page(s) (article)] (46 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams & Wilkins, Hagerstown, MD, ETATS-UNIS  (1979) (Revue)

Mots-clés anglais / English Keywords

Hepatic disease

;

Digestive diseases

;

Peroxidation

;

Lipids

;

Human

;

Antioxidant

;

Oxidative stress

;

Oxidant

;

Non alcoholic steatohepatitis

;

Mots-clés français / French Keywords

Foie pathologie

;

Appareil digestif pathologie

;

Peroxydation

;

Lipide

;

Homme

;

Antioxydant

;

Stress oxydatif

;

Oxydant

;

Stéatohépatite non alcoolique

;

Mots-clés espagnols / Spanish Keywords

Hígado patología

;

Aparato digestivo patología

;

Peroxidación

;

Lípido

;

Hombre

;

Antioxidante

;

Estrés oxidativo

;

Oxidante

;

Esteatohepatitis no alcohólica

;

Mots-clés d'auteur / Author Keywords

nonalcoholic fatty liver disease

;

oxidative stress

;

lipid peroxidation

;

total antioxidant capacity

;

Localisation / Location

INIST-CNRS, Cote INIST : 18331, 35400015900450.0100

Nº notice refdoc (ud4) : 18284831



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