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Titre du document / Document title

Hepatitis viruses in non-human primates

Auteur(s) / Author(s)

MAKUWA M. ; SOUQUIERE S. ; TELFER P. ; BOURRY O. ; ROUQUET P. ; KAZANJI M. ; ROQUES P. ; SIMON F. ;

Résumé / Abstract

Background Previous epidemiological studies of rural human populations in Gabon reveal a high prevalence of human hepatitis A, B, C and D viruses. In order to investigate the prevalence of the blood-born hepatitis viruses in apes and monkeys living in the same area, we performed an epidemiological survey of HBV, HCV and HDV in wild-born non-human primates. Methods We tested 441 wild-born non-human primates from Gabon and Congo and 132 imported monkeys for the presence of serological markers of HBV, HCV and HDV infections. Results None of Cercopithecidae monkeys were reactive against HBV/HDV and HCV. In contrast, 29.2% of wild-born great apes (154 chimpanzees and 14 gorillas) were positive for HBV serological markers. Nine chimpanzees were in the replicative phase of HBV infection. None of these HBV infected chimpanzees exhibited symptoms or significant changes in serum clinical chemistry related to HBV infection. Conclusions The negativity to HCV-related viruses and the negativity of the Cercopithecidae species tested against HBV/HDV do not allow us to definitively rule out the presence of an animal counterpart of human hepatitis viruses in non-human primates.

Revue / Journal Title

Journal of medical primatology    ISSN  0047-2565   CODEN JMPMAO 

Source / Source

2006, vol. 35, no6, pp. 384-387 [4 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1972) (Revue)

Mots-clés d'auteur / Author Keywords

HBV/HDV, HCV

;

great apes

;

Cercopithecidae monkeys

;

Gabon

;

Congo

;

Localisation / Location

INIST-CNRS, Cote INIST : 15665, 35400015887509.0090

Nº notice refdoc (ud4) : 18253609



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