Titre du document / Document title

Metabolic factors affecting residual beta cell function assessed by C-peptide secretion in patients with newly diagnosed type 1 diabetes

Auteur(s) / Author(s)

IMDIAB Group, ITALIE
PICARDI A. ; VISALLI N. ; LAURIA A. ; SURACI C. ; BUZZETTI R. ; MEROLA M. K. ; MANFRINI S. ; GUGLIELMI C. ; GENTILUCCI U. V. ; PITOCCO D. ; CRINO A. ; BIZZARRI C. ; CAPPA M. ; POZZILLI P. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Résumé / Abstract

Background: In recent onset of type 1 diabetes, the residual beta cell function, assessed by baseline and/or stimulated C-peptide secretion, can be a useful parameter to establish the extension of beta cell destruction. How metabolic parameters at diagnosis influence residual C-peptide secretion is not well established. Patients and Methods: We analyzed 553 consecutive patients with recent onset (< 4 weeks) of type 1 diabetes (250 females and 303 males, mean age 15 ± 8 years). Baseline and stimulated C-peptide by i.v. glucagon were evaluated using a highly sensitive radio-immunoassay. Metabolic parameters including blood glucose, HbA1c, insulin dose, and BMI were also evaluated. Results: Baseline and stimulated C-peptide were 0.26±0.22 and 0.47±0.38 nmol/l and correlated positively with age (p < 0.001). There was no significant correlation between C-peptide and blood glucose at diagnosis. BMI was positively correlated with both baseline and stimulated C-peptide secretion (p<0.001). By contrast, HbA1c levels inversely correlated with both baseline and stimulated C-peptide secretion (p<0.001). Conclusion: In type 1 diabetes at diagnosis, baseline and stimulated C-peptide are higher in pubertal and young adult patients compared with pre-pubertal patients suggesting that such parameter can be used as an end point marker for studies aimed at protecting and/or restoring beta cells in patients with substantial beta cell function. High levels of HbA1c and lower BMI are dependent variables of C-peptide values.

Revue / Journal Title

Hormone and metabolic research   ISSN 0018-5043   CODEN HMMRA2 

Source / Source

2006, vol. 38, n^o10, pp. 668-672 [5 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Thieme, Stuttgart, ALLEMAGNE  (1969) (Revue)

Mots-clés d'auteur / Author Keywords

Baseline and stimulated C-peptide, type 1 diabetes ; HbA1c ; insulin dose ;

Localisation / Location

INIST-CNRS, Cote INIST : 14356, 35400014306436.0080