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Titre du document / Document title

In vitro evaluation of effects of two ghanaian plants relevant to wound healing

Auteur(s) / Author(s)

MENSAH Abraham Y. (1) ; HOUGHTON Peter J. (2) ; DICKSON Rita A. (1) ; FLEISCHER T. C. (1) ; HEINRICH M. (3) ; BREMNER P. (3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pharmacognosy, Faculty of Pharmacy, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, GHANA
(2) Pharmacognosy Research Laboratories, Department of Pharmacy, King's College London, 150 Stamford Street, London SE1 9NH, ROYAUME-UNI
(3) Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, ROYAUME-UNI

Résumé / Abstract

Commelina diffusa and Spathodea campanulata are used as wound-healing agents in Ashanti traditional medicine in Ghana. The methanol extracts of Commelina diffusa herb and Spathodea campanulata bark showed some level of antimicrobial activity with C. diffusa exhibiting selective antifungal activity against Trichophyton species. The extracts reduced the peroxidation of bovine brain extract with an IC50 value of 1.39 mg/mL and 0.24 mg/mL, respectively. In addition the extracts also exhibited significant antioxidant activity by protecting MRC-5 cells from hydrogen peroxide induced oxidant injury at concentrations between 1 μg/mL and 10 μg/mL. The extracts showed no inhibition of NF-κB at 100 μg/mL. The antioxidant activities and antimicrobial activities suggest that the use of the plants in wound healing may be based on antioxidant and antiseptic effects of its constituents.

Revue / Journal Title

PTR. Phytotherapy research    ISSN  0951-418X 

Source / Source

2006, vol. 20, no11, pp. 941-944 [4 page(s) (article)] (23 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Chichester, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

Herbaceous plant

;

Spermatophyta

;

Angiospermae

;

Monocotyledones

;

Thallophyta

;

Commelinaceae

;

Plant origin

;

Pharmacognosy

;

Peroxidation

;

Lipids

;

Bacteria

;

Fungi

;

Healing agent

;

Wound

;

Medicinal plant

;

Evaluation

;

In vitro

;

Mots-clés français / French Keywords

Plante herbacée

;

Spermatophyta

;

Angiospermae

;

Monocotyledones

;

Thallophyta

;

Commelina

;

Commelinaceae

;

Origine végétale

;

Pharmacognosie

;

Peroxydation

;

Lipide

;

Bactérie

;

Fungi

;

Cicatrisant

;

Plaie

;

Plante médicinale

;

Evaluation

;

In vitro

;

Mots-clés espagnols / Spanish Keywords

Planta herbácea

;

Spermatophyta

;

Angiospermae

;

Monocotyledones

;

Thallophyta

;

Commelinaceae

;

Origen vegetal

;

Farmacognosia

;

Peroxidación

;

Lípido

;

Bacteria

;

Fungi

;

Cicatrizante

;

Herida

;

Planta medicinal

;

Evaluación

;

In vitro

;

Mots-clés d'auteur / Author Keywords

Commelina diffusa

;

Spathodea campanulata

;

ringworm fungi

;

bacteria

;

wound healing

;

lipid peroxidation

;

Localisation / Location

INIST-CNRS, Cote INIST : 21695, 35400014308697.0030

Nº notice refdoc (ud4) : 18251637



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