Titre du document / Document title
In vitro evaluation of effects of two ghanaian plants relevant to wound healing
Auteur(s) / Author(s)
MENSAH Abraham Y. (1) ;
HOUGHTON Peter J. (2) ;
DICKSON Rita A. (1) ;
FLEISCHER T. C. (1) ;
HEINRICH M. (3) ;
BREMNER P. (3) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Pharmacognosy, Faculty of Pharmacy, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, GHANA
(2) Pharmacognosy Research Laboratories, Department of Pharmacy, King's College London, 150 Stamford Street, London SE1 9NH, ROYAUME-UNI
(3) Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, ROYAUME-UNI
Résumé / Abstract
Commelina diffusa and Spathodea campanulata are used as wound-healing agents in Ashanti traditional medicine in Ghana. The methanol extracts of Commelina diffusa herb and Spathodea campanulata bark showed some level of antimicrobial activity with C. diffusa exhibiting selective antifungal activity against Trichophyton species. The extracts reduced the peroxidation of bovine brain extract with an IC
50 value of 1.39 mg/mL and 0.24 mg/mL, respectively. In addition the extracts also exhibited significant antioxidant activity by protecting MRC-5 cells from hydrogen peroxide induced oxidant injury at concentrations between 1 μg/mL and 10 μg/mL. The extracts showed no inhibition of NF-κB at 100 μg/mL. The antioxidant activities and antimicrobial activities suggest that the use of the plants in wound healing may be based on antioxidant and antiseptic effects of its constituents.
Revue / Journal Title
PTR. Phytotherapy research
ISSN
0951-418X
Source / Source
2006, vol. 20, n
o11, pp. 941-944 [4 page(s) (article)] (23 ref.)
Langue / Language
Anglais
Editeur / Publisher
Wiley, Chichester, ROYAUME-UNI
(1987)
(Revue)
Mots-clés anglais / English Keywords
Herbaceous plant ;
Spermatophyta ;
Angiospermae ;
Monocotyledones ;
Thallophyta ;
Commelinaceae ;
Plant origin ;
Pharmacognosy ;
Peroxidation ;
Lipids ;
Bacteria ;
Fungi ;
Healing agent ;
Wound ;
Medicinal plant ;
Evaluation ;
In vitro ;
Mots-clés français / French Keywords
Plante herbacée ;
Spermatophyta ;
Angiospermae ;
Monocotyledones ;
Thallophyta ;
Commelina ;
Commelinaceae ;
Origine végétale ;
Pharmacognosie ;
Peroxydation ;
Lipide ;
Bactérie ;
Fungi ;
Cicatrisant ;
Plaie ;
Plante médicinale ;
Evaluation ;
In vitro ;
Mots-clés espagnols / Spanish Keywords
Planta herbácea ;
Spermatophyta ;
Angiospermae ;
Monocotyledones ;
Thallophyta ;
Commelinaceae ;
Origen vegetal ;
Farmacognosia ;
Peroxidación ;
Lípido ;
Bacteria ;
Fungi ;
Cicatrizante ;
Herida ;
Planta medicinal ;
Evaluación ;
In vitro ;
Mots-clés d'auteur / Author Keywords
Commelina diffusa ;
Spathodea campanulata ;
ringworm fungi ;
bacteria ;
wound healing ;
lipid peroxidation ;
Localisation / Location
INIST-CNRS, Cote INIST : 21695, 35400014308697.0030
Nº notice refdoc (ud4) : 18251637
