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Titre du document / Document title

Functional connectivity in a baseline resting-state network in autism

Auteur(s) / Author(s)

CHERKASSKY Vladimir L. (1) ; KANA Rajesh K. (1) ; KELLER Timothy A. (1) ; ADAM JUST Marcel (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Center for Cognitive Brain Imaging, Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania, ETATS-UNIS

Résumé / Abstract

Brain activity in people with high-functioning autism has been shown to be atypical in a number of ways, including reduced synchronization across areas of activation measured by functional magnetic resonance imaging. This activation atypicality has been observed mostly during the performance of cognitive tasks. This study compares the resting-state network of 57 participants with autism and 57 control participants matched for age and intelligence quotient.The results indicate that both groups have a resting-state network that is very similar both in volume and in organization, but in autism this network is much more loosely connected. This functional underconnectivity was observed in the anterior-posterior connections. The results expand the theory of cortical underconnectivity in autism to the resting state of the brain.

Revue / Journal Title

Neuroreport    ISSN  0959-4965 

Source / Source

2006, vol. 17, no16, pp. 1687-1690 [4 page(s) (article)] (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams & Wilkins, Hagerstown, MD, ETATS-UNIS  (1990) (Revue)

Mots-clés anglais / English Keywords

Developmental disorder

;

Human

;

Autism

;

Nuclear magnetic resonance imaging

;

Functional imaging

;

Corpus callosum

;

Mots-clés français / French Keywords

Trouble développement

;

Homme

;

Autisme

;

Imagerie RMN

;

Imagerie fonctionnelle

;

Corps calleux

;

Mots-clés espagnols / Spanish Keywords

Trastorno desarrollo

;

Hombre

;

Autismo

;

Imaginería RMN

;

Imaginería funcional

;

Cuerpo calloso

;

Mots-clés d'auteur / Author Keywords

autism

;

corpus callosum

;

functional connectivity

;

functional magnetic resonance imaging (fMRI)

;

resting-state network

;

Localisation / Location

INIST-CNRS, Cote INIST : 22534, 35400015884266.0060

Nº notice refdoc (ud4) : 18245466



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