Titre du document / Document title
Intake of 13C-4 creatine enables simultaneous assessment of creatine and phosphocreatine pools in human skeletal muscle by 13C MR spectroscopy
Auteur(s) / Author(s)KAN H. E.
VAN DER GRAAF M.
KLOMP D. W. J.
VLAK M. H. M.
PADBERG G. W.
Résumé / Abstract
The feasibility of a novel method for the noninvasive and local assessment of creatine (Cr) and phosphocreatine (PCr) dynamics in human skeletal muscle based on 13
C magnetic resonance (MR) spectroscopy is presented. A high dose of Cr, labeled at the guanidino C-4 position with 13
C 11% enrichment, was administered orally to a human subject for 5 days. Using a surface coil, 13
C MR spectra of the lower leg were acquired on a 1.5T MR system at regular time intervals during and after Cr supplementation. An almost twofold increase in the intensities of the resolved PCr and Cr 13
C-4 signals was observed during this period. The slow decrease in these signals to normal values after supplementation reflects the slow daily turnover of Cr. The PCr/Cr ratio did not appear to change over the whole measurement period. During exercise of the leg, reversible changes in PCr and Cr signals were observed, reflecting conversion by the Cr kinase reaction.
Revue / Journal TitleMagnetic resonance in medicine
Source / Source
2006, vol. 56, no
5, pp. 953-957 [5 page(s) (article)]
Langue / Language
Editeur / Publisher
Williams & Wilkins, Baltimore, MD, ETATS-UNIS
Mots-clés d'auteur / Author Keywords
Localisation / Location
INIST-CNRS, Cote INIST : 20644, 35400015882104.0020
Nº notice refdoc (ud4) : 18230955