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Titre du document / Document title

Hypoxia can contribute to the induction of the Epstein-Barr virus (EBV) lytic cycle

Auteur(s) / Author(s)

JIANG Ju-Hong (1) ; NA WANG (2) ; ANG LI (2) ; LIAO Wen-Ting (2) ; PAN Zhi-Gang (2) ; MAI Shi-Juan (2) ; LI Da-Jiang (2) ; ZENG Mu-Sheng (2) ; WEN Jian-Ming (1) ; ZENG Yi-Xin (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, 651 Dong-Feng Road East, Guangzhou 510080, CHINE
(2) State Key Laboratory of Oncology in South China and The Department of Experimental Research, Cancer Center, Sun Yat-sen University, 651 Dong-Feng Road East, Guangzhou 510060, CHINE

Résumé / Abstract

Background: Like other herpes viruses, latent Epstein-Barr virus (EBV) infection can be reactivated to lytic replication. Reactivation can be achieved by treatment with various reagents, including tetradecanoyl phorbol acetate (TPA) and Ca2+ ionophores. Relatively little is known about the physiological factors related to reactivation of EBV. Previous studies have demonstrated that G0/G1 cell cycle arrest is associated with EBV activation, and that hypoxic conditions can induce cell cycle arrest. In the present study we investigated the effect of hypoxia on reactivation of EBV. Objective and methods: Hypoxic culture conditions were established and the expression of Zta protein and the number of EBV DNA copies were measured in B95-8 cells maintained under these conditions. Results: Hypoxia treatment not only increased the expression of the EBV immediate-early protein Zta (which mediates the switch between the latent and lytic form of infection), but also increased the number of EBV DNA copies in B95-8 cells. Conclusions: EBV in latent infection can be activated to lytic infection by hypoxia treatment.

Revue / Journal Title

Journal of clinical virology    ISSN  1386-6532 

Source / Source

2006, vol. 37, no2, pp. 98-103 [6 page(s) (article)] (29 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1998) (Revue)

Mots-clés anglais / English Keywords

Malignant tumor

;

Pharynx disease

;

ENT disease

;

Virus

;

Herpesviridae

;

Gammaherpesvirinae

;

Oxygen

;

Nasopharynx carcinoma

;

Virology

;

Microbiology

;

Hypoxia

;

Epstein Barr virus

;

Mots-clés français / French Keywords

Tumeur maligne

;

Pharynx pathologie

;

ORL pathologie

;

Virus

;

Herpesviridae

;

Gammaherpesvirinae

;

Oxygène

;

Carcinome nasopharynx

;

Virologie

;

Microbiologie

;

Hypoxie

;

Virus Epstein Barr

;

Mots-clés espagnols / Spanish Keywords

Tumor maligno

;

Faringe patología

;

ORL patología

;

Virus

;

Herpesviridae

;

Gammaherpesvirinae

;

Oxígeno

;

Carcinoma nasofaringe

;

Virología

;

Microbiología

;

Hipoxia

;

Epstein Barr virus

;

Mots-clés d'auteur / Author Keywords

Hypoxia

;

Epstein-Barr virus

;

Reactivation

;

Nasopharyngeal carcinoma

;

Localisation / Location

INIST-CNRS, Cote INIST : 26272, 35400014295050.0040

Nº notice refdoc (ud4) : 18173331



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