Titre du document / Document title

Normalization of hyperinsulinemia by chronic opioid receptor blockade in hyperandrogenemic women

Auteur(s) / Author(s)

HADZIOMEROVIC Dijana ⁽¹⁾ ; RABENBAUER Bernhard ⁽¹⁾ ; WILDT Ludwig ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Innsbruck, AUTRICHE

Résumé / Abstract

Objective: Evaluation of the effects of naltrexone on hyperinsulinemia and hyperandrogenemia in hyperandrogenemic, hyperinsulinemic women. Design: Controlled clinical study. Setting: Department of Gynecologic Endocrinology and Reproductive Medicine, Center of Obstetrics and Gynecology, Medical University of Innsbruck, Austria. Patient(s): Thirty-nine hyperandrogenemic, hyperinsulinemic women were studied. Intervention(s): Women were treated with naltrexone (50 mg/d) for ≥3 weeks. Main Outcome Measure(s): Body mass index (BMI), gonadotropin (LH, FSH) and androgen (T, free T, DHEAS) levels, and plasma levels of glucose, insulin, and C-peptide, during a standard 75-g oral glucose tolerance test (OGTT), were determined before and during chronic opiate receptor blockade. Result(s): The BMI did not change during therapy. When OGTT was repeated after treatment with naltrexone, glucose levels were not different from those before treatment. Insulin response, however, had dramatically declined. We also observed a significant decrease in the levels of serum androgens. Conclusion(s): Hyperinsulinemia associated with hyperandrogenemia can be improved or completely abolished by chronic opiate receptor blockade. This observation suggests that endogenous opiates play a critical role in the process leading to hyperinsulinemia in hyperandrogenemia.

Revue / Journal Title

Fertility and sterility   ISSN 0015-0282   CODEN FESTAS 

Source / Source

2006, vol. 86, n^o3, pp. 651-657 [7 page(s) (article)] (43 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier Science, New York, NY, ETATS-UNIS  (1950) (Revue)

Mots-clés anglais / English Keywords

Masculinization ; Skin disease ; Morphinan derivatives ; Endocrinopathy ; Hair ; Fertility ; Hyperandrogenism ; Opiates ; Endogenous ; Woman ; Adult ; Hirsutism ; Female ; Human ; Naltrexone ; Opioid receptor ; Chronic ; Hyperinsulinemia ;

Mots-clés français / French Keywords

Masculinisation ; Peau pathologie ; Morphinane dérivé ; Endocrinopathie ; Poil ; Fertilité ; Hyperandrogénie ; Opiacés ; Endogène ; Femme ; Adulte ; Hirsutisme ; Femelle ; Homme ; Naltrexone ; Récepteur opiacé ; Chronique ; Hyperinsulinémie ;

Mots-clés espagnols / Spanish Keywords

Masculinizacion ; Piel patología ; Morphinano derivado ; Endocrinopatía ; Pelo ; Fertilidad ; Hiperandrogenismo ; Opiados ; Endógeno ; Mujer ; Adulto ; Hirsutismo ; Hembra ; Hombre ; Naltrexona ; Receptor opiáceo ; Crónico ; Hiperinsulinemia ;

Mots-clés d'auteur / Author Keywords

Hyperinsulinemia ; endogenous opiates ; naltrexone ; hyperandrogenemia ; hirsutism ;

Localisation / Location

INIST-CNRS, Cote INIST : 4120, 35400015228191.0240