Titre du document / Document title

Fasting and post-prandial glycemia and their correlation with glycated hemoglobin in type 2 diabetes

Auteur(s) / Author(s)

MONAMI M. ; LAMANNA C. ; LAMBERTUCCI L. ; LONGO R. ; COCCA C. ; ADDANTE F. ; LOTTI E. ; MASOTTI G. ; MARCHIONNI N. ; MANNUCCI E. ;

Résumé / Abstract

Objective: The relative contribution of fasting and post-prandial glucose to glycated hemoglobin (HbA_1c) is controversial. In the present study, we assessed the relationship with HbA_1c of fasting and post-prandial glucose measured in a more naturalistic setting, through home glucose self-monitoring or with a continuous glucose monitoring system (CGM). Materials and methods: A consecutive series of 300 patients with Type 2 diabetes were enrolled in the study, provided that they performed blood glucose self-monitoring. HbA_1c and fasting plasma glucose (FPG) were measured at enrolment. Results: Both fasting plasma and capillary glucose showed a significant correlation with HbA_1c (r=0.66 and 0.61, respectively; p<0.001). When home glucose monitoring was considered, both mean fasting and post-prandial glucose showed a significant correlation with HbA_1c (r=0.71 and 0.73, respectively). In patients in the lower tertile of body mass index (BMI), HbA_1c showed a significant correlation at multivariate analysis with post-prandial glucose, but not with fasting glucose. In patients with HbA_1c >7%, both fasting and post-prandial glucose showed a significant correlation, after adjustment for age and BMI, with HbA_1c (both p<0.01); conversely, in those with HbA_1c ≤7%, such a correlation could be observed for fasting (p<0.01), but not for post-prandial glucose. Conclusion: In conclusion, both fasting and post-prandial glucose contribute to the determination of HbA_1c. Home glucose self-monitoring appears to provide a more accurate assessment of metabolic control than a single plasma glucose measurement in experimental conditions. Fasting glucose could provide a greater contribution to HbA_1c in patients with lower HbA_1c, while post-prandial glucose seems to play a major role in leaner Type 2 diabetic subjects.

Revue / Journal Title

Journal of endocrinological investigation   ISSN 0391-4097   CODEN JEIND7 

Source / Source

2006, vol. 29, n^o7, pp. 619-624 [6 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Kurtis, Milano, ITALIE  (1978) (Revue)

Mots-clés d'auteur / Author Keywords

Diabetes mellitus ; glycated hemoglobin ; fasting glucose ; post-prandial glucose ; home glucose self monitoring ; continuous glucose monitoring ;

Localisation / Location

INIST-CNRS, Cote INIST : 18833, 35400013932554.0060