Titre du document / Document title

Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women : a randomized controlled trial

Auteur(s) / Author(s)

HACKMAN R. M. ⁽¹⁾ ; HAVEL P. J. ⁽¹⁾ ; SCHWARTZ H. J. ⁽²⁾ ; RUTLEDGE J. C. ⁽²⁾ ; WATNIK M. R. ⁽³⁾ ; NOCETI E. M. ⁽¹⁾ ; STOHS S. J. ⁽⁴⁾ ; STERN J. S. ^{(1 2)} ; KEEN C. L. ^{(1 2)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Nutrition, University of California, Davis, CA, ETATS-UNIS
⁽²⁾ Department of Internal Medicine, University of California, Davis, CA, ETATS-UNIS
⁽³⁾ Department of Statistics, California State University, East Bay, CA, ETATS-UNIS
⁽⁴⁾ Department of Pharmacy Science, Creighton University, Omaha, ETATS-UNIS

Résumé / Abstract

Objective: To determine the safety and efficacy of a dietary supplement with a low dose of ephedra and caffeine in overweight/ obese premenopausal female subjects. Design: A 9-month, double-blind, randomized control study compared the efficacy and safety of a dietary supplement with ephedra and caffeine to a control supplement. Subjects: Sixty-one healthy, premenopausal women with body mass index (BMI) from 27 to 39 kg/m² were randomly assigned and received a dietary supplement (40mg/day ephedra alkaloids, 100 mg/day caffeine, high potency mixture of vitamins, minerals, omega-3 fatty acids) or a control supplement for 9 months. Measurements: Efficacy: changes in body weight, body composition, lipids, insulin, leptin, adiponectin, ghrelin, and self-reports of physical activity, diet and quality of life indices. Safety: blood pressure, heart rate, electrocardiograms, urinalysis, blood histology, serum chemistry measures and self-reported symptoms. Results: Forty-one women completed the study. The treatment group lost significantly more body weight (-7.18 kg) and body fat (-5.33 kg) than the control group (-2.25 and -0.99 kg, respectively), and showed significant declines in heart rate, serum cholesterol, triglycerides, cholesterol to high-density lipoprotein ratio, glucose, fasting insulin, and leptin. Blood pressure, electrocardiograms, other clinical chemistry measures, blood histology, urinalysis, and self-reported physical activity were similar in the groups. Minor symptoms included dry mouth, insomnia, nervousness and palpitations. The treatment group reported more energy and decreased appetite compared to controls and scored higher on a quality of life domain assessing vitality. Conclusion: A dietary supplement containing a low potency ephedra/caffeine mixture appeared safe and effective in causing loss of weight and body fat, and improving several metabolic parameters, including insulin sensitivity and lipid profiles when tested under physician supervision. Such supplements could be a useful tool to assist with weight loss.

Revue / Journal Title

International journal of obesity   ISSN 0307-0565   CODEN IJOBDP 

Source / Source

2006, vol. 30, n^o10, pp. 1545-1556 [12 page(s) (article)] (47 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing, Basingstoke, ROYAUME-UNI  (1977) (Revue)

Mots-clés anglais / English Keywords

Pancreatic hormone ; Nutrition disorder ; Xanthine derivatives ; Adipocytokine ; Randomised controlled trial ; Nutritional status ; CNS stimulant ; Respiratory analeptic ; Psychotropic ; Nutrition ; Leptin ; Insulin ; Lipids ; Supplementation ; Feeding ; Clinical trial ; Randomization ; Woman ; Female ; Human ; Risk factor ; Metabolic diseases ; Improvement ; Obesity ; Weight loss ; Medicinal plant ; Caffeine ;

Mots-clés français / French Keywords

Hormone pancréatique ; Trouble nutrition ; Xanthine dérivé ; Adipocytokine ; Essai randomisé contrôlé ; Ephedra ; Etat nutritionnel ; Stimulant SNC ; Analeptique respiratoire ; Psychotrope ; Nutrition ; Leptine ; Insuline ; Lipide ; Supplémentation ; Alimentation ; Essai clinique ; Randomisation ; Femme ; Femelle ; Homme ; Facteur risque ; Métabolisme pathologie ; Amélioration ; Obésité ; Perte poids ; Plante médicinale ; Caféine ;

Mots-clés espagnols / Spanish Keywords

Hormona pancreática ; Trastorno nutricíon ; Xantina derivado ; Ensayo clínico aleatorio ; Estado nutricional ; Estimulante SNC ; Analéptico respiratorio ; Psicotropo ; Nutrición ; Leptina ; Insulina ; Lípido ; Suplementación ; Alimentación ; Ensayo clínico ; Aleatorización ; Mujer ; Hembra ; Hombre ; Factor riesgo ; Metabolismo patología ; Mejora ; Obesidad ; Adelgazamiento ; Planta medicinal ; Cafeína ;

Mots-clés d'auteur / Author Keywords

(MeSH) ephedra ; weight loss ; dietary supplement ; lipids ; insulin ; leptin ;

Localisation / Location

INIST-CNRS, Cote INIST : 18243, 35400015720163.0120