Titre du document / Document title

The means shape the ends : The localization and function of FMRP

Auteur(s) / Author(s)

ANTAR Laura N. ⁽¹⁾ ; BASSELL Gary J. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Neuroscience, Rose F. Kennedy Center for Mental Retardation 1410 Pelham Parkway, Albert Einstein College of Medicine, Bronx NY 10461, ETATS-UNIS

Résumé / Abstract

Understanding the mechanistic function of the Fragile X Mental Retardation Protein (FMRP) in neurons is needed to understand the molecular basis of Fragile X Syndrome, the most common inherited form of mental retardation. While a spine defect is associated with the absence of the mRNA binding protein FMRP, it is unclear how its absence leads to synaptic defects that underlie the cognitive impairments in FXS. FMRP may regulate dendritic trafficking and localization of mRNAs to subsynaptic sites in an activity-dependent manner, where regulation of local protein synthesis influences synaptic structure and plasticity. To understand the role ofFMRP at the synapse, an examination of its journey along the dendritic branches of the most polarized cell in the human body, and brief examination of the partners it associates with en route, becomes of paramount importance.

Source / Source

The molecular basis of fragile X syndrome
2005  , pp. 171-199[Note(s) :  [265 p.]] [Document : 29 p.] (104 ref.) ISBN 81-7736-257-7 ;  Illustration : Figure ;

Langue / Language

Anglais

Editeur / Publisher

Research Signpost, Trivandrum, India, INDE  (2005) (Monographie)

Mots-clés anglais / English Keywords

Chromosome fragility ; Genetic determinism ; Fragile X syndrome ;

Mots-clés français / French Keywords

Fragilité chromosomique ; Déterminisme génétique ; X fragile syndrome ;

Mots-clés espagnols / Spanish Keywords

Fragilidad cromosómica ; Determinismo genético ; X frágil síndrome ;

Localisation / Location

INIST-CNRS, Cote INIST : L 30477, 35400015365456.0110