Titre du document / Document title

Mu and kappa opioid receptor agonists antagonize icilin-induced wet-dog shaking in rats

Auteur(s) / Author(s)

WERKHEISER Jennifer L. ⁽¹⁾ ; RAWLS Scott M. ⁽²⁾ ; COWAN Alan ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Departments of Pharmacology, Temple University Health Sciences Center, Philadelphia, PA 19140, ETATS-UNIS
⁽²⁾ Pharmaceutical Sciences, Temple University Health Sciences Center, Philadelphia, PA 19140, ETATS-UNIS

Résumé / Abstract

Icilin is a cooling agent that precipitates vigorous wet-dog shakes in rats after acute i.p. administration. Recent research has emphasized the peripheral agonist properties (e.g. activation of transient receptor potential channels, TRPM8 and TRPA1) of icilin rather than its unusual and pronounced behavioral effects, often classified as quasi-morphine withdrawal. We tested selective opioid receptor agonists against icilin-induced wet-dog shakes in rats. Shaking was antagonized following s.c. pretreatment with the mu agonists, morphine (1, 2, 3 mg/kg) and buprenorphine (0.10 mg/kg) or the kappa agonists, nalfurafine (0.02, 0.04 mg/kg) and U50,488H (5 mg/kg). Pretreatment with ICI 204,448 (1, 5, 10 mg/kg), the peripherally directed kappa agonist, or the delta agonist, SNC 80 (0.30, 1, 3, 10 mg/kg), had no marked effect on the incidence of shaking. We conclude that (a) icilin can trigger shaking via interactions within the central nervous system and (b) mu and kappa opioid receptors are involved in suppressing this stimulant behavior.

Revue / Journal Title

European journal of pharmacology   ISSN 0014-2999   CODEN EJPHAZ 

Source / Source

2006, vol. 547, n^o1-3, pp. 101-105 [5 page(s) (article)] (39 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1967) (Revue)

Mots-clés anglais / English Keywords

Antagonist ; Opiates ; Rodentia ; Vertebrata ; Mammalia ; Carnivora ; Fissipedia ; Narcotic analgesic ; Nalfurafine ; Drug addiction ; Buprenorphine ; Morphine ; Rat ; Dog ; Animal ; Agonist ; κ Opioid receptor ;

Mots-clés français / French Keywords

Antagoniste ; Opiacés ; Rodentia ; Vertebrata ; Mammalia ; Carnivora ; Fissipedia ; Analgésique narcotique ; Nalfurafine ; Toxicomanie ; Buprénorphine ; Morphine ; Rat ; Chien ; Animal ; Agoniste ; Récepteur opiacé κ ;

Mots-clés espagnols / Spanish Keywords

Antagonista ; Opiados ; Rodentia ; Vertebrata ; Mammalia ; Carnivora ; Fissipedia ; Analgésico narcotico ; Nalfurafina ; Toxicomanía ; Buprenorfina ; Morfina ; Rata ; Perro ; Animal ; Agonista ; Receptor opiáceo κ ;

Mots-clés d'auteur / Author Keywords

Wet-dog shakes ; Icilin ; Morphine ; Buprenorphine ; ICI 204,448 ; Nalfurafine ; U50,488H ; SNC 80 ;

Localisation / Location

INIST-CNRS, Cote INIST : 13322, 35400015716773.0130