Titre du document / Document title
Association between the dihydrotestosterone level in the prostate and prostate cancer aggressiveness using the gleason score
Auteur(s) / Author(s)
NISHIYAMA Tsutomu (1) ;
IKARASHI Toshihiko (2) ;
HASHIMOTO Yutaka (3) ;
SUZUKI Kazuya (1) ;
TAKAHASHI Kota (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JAPON
(2) Department of Pathology, Niigataken Kouseiren Byori Center, Nagaoka, JAPON
(3) Pharmaceuticals Group, Nippon Kayaku Co., Ltd, Tokyo, JAPON
Résumé / Abstract
Purpose: To our knowledge the association between dihydrotestosterone in the prostate and prostate cancer aggressiveness has not yet been elucidated. We analyzed dihydrotestosterone levels in the prostate and Gleason score in patients diagnosed with clinically localized prostate cancer. Materials and Methods: A total of 81 patients with suspected prostate cancer underwent prostate biopsy. Serum samples were collected before biopsy. Dihydrotestosterone levels in prostatic tissue and serum were analyzed using liquid chromatography/electrospray ionization-mass spectrometry after polar derivatization. Results: A total of 47 patients were diagnosed with stages T1 to T3N0M0 prostate cancer and 34 were diagnosed with no malignancy. Of the 47 patients 32 had a Gleason score of 6 or less and 15 had a score of 7 to 10. Dihydrotestosterone in prostatic tissue in patients with Gleason score 7 to 10 disease was significantly lower than in those with Gleason score 6 or less disease (p = 0.025). Gleason score correlated with the testosterone-to-serum dihydrotestosterone ratio (rs = 0.329, p = 0.038). Conclusions: Patients with Gleason score 7 to 10 prostate cancer have low dihydrotestosterone in the prostate, although there were no significant differences between patients with Gleason score 7 to 10 vs 6 or less prostate cancer with respect to serum androgens. Low dihydrotestosterone in cases of aggressive prostate cancer is probably sufficient to activate androgen receptor expression and propagate tumor growth.
Revue / Journal Title
The Journal of urology
ISSN
0022-5347
CODEN JOURAA
Source / Source
2006, vol. 176 (1), n
o4, pp. 1387-1391 [5 page(s) (article)] (20 ref.)
Langue / Language
Anglais
Editeur / Publisher
Lippincott Williams & Wilkins, Hagerstown, MD, ETATS-UNIS
(1917)
(Revue)
Mots-clés anglais / English Keywords
Sex steroid hormone ;
Malignant tumor ;
Urinary system disease ;
Male genital diseases ;
Prostate disease ;
Nephrology ;
Gleason score ;
Urology ;
Androgen ;
Histological grading ;
Prostate tumor ;
Malignancy ;
Aggressiveness ;
Histopathology ;
Dihydrotestosterone ;
Association ;
Prostate cancer ;
Mots-clés français / French Keywords
Hormone stéroïde sexuelle ;
Tumeur maligne ;
Appareil urinaire pathologie ;
Appareil génital mâle pathologie ;
Prostate pathologie ;
Néphrologie ;
Score Gleason ;
Urologie ;
Androgène ;
Grade histologique ;
Tumeur prostate ;
Malignité ;
Agressivité ;
Histopathologie ;
Dihydrotestostérone ;
Association ;
Cancer prostate ;
Mots-clés espagnols / Spanish Keywords
Hormona esteroide sexual ;
Tumor maligno ;
Aparato urinario patología ;
Aparato genital macho patología ;
Prostata patología ;
Nefrología ;
Cuenta Gleason ;
Urología ;
Andrógeno ;
Grado histológico ;
Tumor prostata ;
Malignidad ;
Agresividad ;
Histopatología ;
Dihidrotestosterona ;
Asociación ;
Cáncer de la próstata ;
Mots-clés d'auteur / Author Keywords
prostate ;
prostatic neoplasms ;
dihydrotestosterone ;
androgens ;
Localisation / Location
INIST-CNRS, Cote INIST : 2081, 35400015713192.0200
Nº notice refdoc (ud4) : 18107663
