Titre du document / Document title

The effect of treatment with moxifloxacin or azithromycin on acute bacterial rhinosinusitis in mice

Auteur(s) / Author(s)

LUXAMEECHANPORN Thongchai ⁽¹⁾ ; BLAIR Christopher ⁽¹⁾ ; KIRTSREESAKUL Virat ⁽¹⁾ ; THOMPSON Kenneth ⁽²⁾ ; NACLERIO Robert M. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Section of Otolaryngology-Head and Neck Surgery, University of Chicago, 5841 South Maryland Avenue, MC 1035, Chicago, IL 60637, ETATS-UNIS
⁽²⁾ Department of Pathology, University of Chicago, Chicago, IL 60637, ETATS-UNIS

Résumé / Abstract

Objective: Acute bacterial rhinosinusitis, which is a major health problem, is treated with antibiotics. We developed a mouse model of acute bacterial rhinosinusitis to gain a better understanding of the pathophysiology of the disease. Our goal was to investigate the response to acute rhinosinusitis when treated with either a bactericidal or a bacteriostatic antibiotic. Methods: C57BL/6 mice were infected intranasally with Streptococcus pneumoniae. One day after inoculation, the mice were treated with either moxifloxacin (bactericidal) or azithromycin (bacteriostatic). Different groups were euthanized during the first five days post-inoculation. Bacterial counts from nasal lavage culture and the cell markers GR1, CD11 b, CD3, CD4, and CD8 in sinus tissue were evaluated by flow cytometry. Results: Azithromycin led to rapid clearance of the bacteria and of the inflammation in contrast to placebo. Surprisingly, moxifloxacin showed a limited effect. Investigations of this limited effect of moxifloxacin suggested a high metabolic clearance, a low concentration at the site of infection, and low persistent post-antibiotic effects of moxifloxacin in mice. Conclusion: Our animal model of acute sinusitis has great utility for studying the disease, but the difference between mice and man must always be considered in making extrapolations from animal experiments to the human experience.

Revue / Journal Title

International journal of infectious diseases   ISSN 1201-9712 

Source / Source

2006, vol. 10, n^o5, pp. 401-406 [6 page(s) (article)] (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1996) (Revue)

Mots-clés anglais / English Keywords

Protein synthesis inhibitor ; Paranasal sinus disease ; Nose disease ; ENT disease ; Macrolide ; Quinolone derivatives ; Fluoroquinolone derivatives ; Streptococcal infection ; Vertebrata ; Mammalia ; Rodentia ; Bacteria ; Micrococcales ; Streptococcaceae ; Infection ; Antibiotic ; Antibacterial agent ; Pneumococcal infection ; Mouse ; Streptococcus pneumoniae ; Animal ; Acute ; Moxifloxacin ; Treatment ; Azithromycin ; Sinusitis ; Rhinitis ; Bacteriosis ;

Mots-clés français / French Keywords

Inhibiteur synthèse protéique ; Sinus face pathologie ; Nez pathologie ; ORL pathologie ; Macrolide ; Quinolone dérivé ; Fluoroquinolone dérivé ; Streptococcie ; Vertebrata ; Mammalia ; Rodentia ; Bactérie ; Micrococcales ; Streptococcaceae ; Infection ; Antibiotique ; Antibactérien ; Pneumococcie ; Souris ; Streptococcus pneumoniae ; Animal ; Aigu ; Moxifloxacine ; Traitement ; Azithromycine ; Sinusite ; Rhinite ; Bactériose ;

Mots-clés espagnols / Spanish Keywords

Inhibidor síntesis proteica ; Seno paranasal patología ; Nariz patología ; ORL patología ; Macrólido ; Quinolone derivado ; Fluoroquinolone derivado ; Estreptococia ; Vertebrata ; Mammalia ; Rodentia ; Bacteria ; Micrococcales ; Streptococcaceae ; Infección ; Antibiótico ; Antibacteriano ; Neumococia ; Ratón ; Streptococcus pneumoniae ; Animal ; Agudo ; Moxifloxacino ; Tratamiento ; Azitromicina ; Sinusitis ; Rinitis ; Bacteriosis ;

Mots-clés d'auteur / Author Keywords

Acute sinusitis ; Azithromycin ; Mice ; Moxifloxacin ; Streptococcus pneumoniae ;

Localisation / Location

INIST-CNRS, Cote INIST : 26659, 35400014219159.0090