Titre du document / Document title

Type 1 diabetes mellitus associated with nephrotic syndrome

Auteur(s) / Author(s)

AGRAS Pinar Isik ; KINIK Sibel Tulgar ; CENGIZ Nurcan ; BASKIN Esra ;

Résumé / Abstract

Nephrotic syndrome (NS) in a patient with diabetes mellitus (DM) first suggests the diagnosis of diabetic nephropathy. However, glomerular diseases other than diabetic nephropathy have been reported in patients with DM. We present a child with type 1 DM (DM1) associated with NS. A 3 year-old boy who was diagnosed with DM1 developed proteinuria in nephrotic range at the 10^th month of follow-up. He had remission on steroid treatment without any problem in glycemic control as he was given tapered daily doses instead of an alternate day regimen. He relapsed at the 7^th month of follow-up, and cyclophosphamide treatment brought about remission. He had HLA A24, DR4 and DR53 antigens in common with previously reported cases of DM-NS association. The immunological basis of these diseases may have a causal effect on the association, but the etiopathogenesis is still unclear.

Revue / Journal Title

Journal of pediatric endocrinology & metabolism   ISSN 0334-018X 

Source / Source

2006, vol. 19, n^o8, pp. 1045-1048 [4 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Freund, Tel Aviv, ISRAEL  (1985) (Revue)

Mots-clés d'auteur / Author Keywords

type 1 diabetes mellitus ; nephrotic syndrome ;

Localisation / Location

INIST-CNRS, Cote INIST : 20997, 35400013356986.0120