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Titre du document / Document title

Tratamiento de la hemocromatosis hereditaria tipo 1 con magnesio oral = Treatment of type 1 hereditary haemochromatosis with oral magnesium

Auteur(s) / Author(s)

ALTES Albert ; ANGELS RUIZ M. ; REMACHA Angel F. ; SARDA Pilar ; BAIGET Montserrat ; SIERRA Jordi ;

Résumé / Abstract

BACKGROUND AND OBJECTIVE: An essential step in the pathogenesis of hereditary hemochromatosis seems to be the increased expression of a duodenal divalent cation transporter (DMT1) responsible for absorption of non-heminic iron2+. The objective of the present study was to ascertain whether the competitive blockade of DMT1 by the administration of high doses of oral Mg2+ reduces iron absorption in patients homozygous for the C282Y mutation. PATIENTS AND METHOD: Iron absorption was evaluated by a low dose iron absorption test in 15 patients before and after treatment with oral magnesium (809.6 mg every 8 hours) for two weeks. RESULTS: We did not observe secondary effects or significant differences in iron absorption before or after magnesium treatment (14.7 μmol/L; 95% confidence interval [Cl], 9.8-19.6 vs 14.9 μmol/L; 95% Cl, 8.5-21.4, P = 0.7). CONCLUSIONS: Treatment with oral magnesium does not reduce iron absorption in homozygous C282Y patients. This treatment can not be used in these subjects.

Revue / Journal Title

Medicina clinica    ISSN  0025-7753 

Source / Source

2006, vol. 126, no16, pp. 611-613 [3 page(s) (article)]

Langue / Language

Espagnol

Editeur / Publisher

Elsevier, Barcelona, ESPAGNE  (1943) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 12388, 35400013345930.0030

Nº notice refdoc (ud4) : 18033292



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