Titre du document / Document title

Study of subcutaneous fat in children with juvenile dermatomyositis

Auteur(s) / Author(s)

VERMA Sumit ⁽¹⁾ ; SINGH Surjit ⁽¹⁾ ; ANIL KUMAR BHALLA ⁽¹⁾ ; KHULLAR Madhu ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Post Graduate Institute of Medical Education and Research, Chandigarh, INDE

Résumé / Abstract

Objective. Lipodystrophy is a recently recognized complication of juvenile dermatomyositis (juvenile DM). Until now, the diagnosis has been based only on the physical appearance of the patient. We quantìfied the patterns of fat distribution in a cohort of patients with juvenile DM. Methods. Twenty patients with juvenile DM were enrolled along with a matching number of controls. Both groups underwent standard anthropometric measurements including assessment of skinfold thickness using Harpenden Skinfold Caliper (Holtain, Dyfed, UK). Glucose tolerance test and serum lipid estimates were performed in the study group but not in controls. Results. Patients with juvenile DM had lower mean weight, height, and mid-upper-arm circumference as compared with controls; these differences were statistically significant (P ≤ 0.05). Eight (40%) of 20 patients had lipodystrophy on physical appearance. When assessed by skinfold caliper, there was loss of subcutaneous fat at the mid-axillary site in 65% of patients, at the subscapular in 60%, and at the suprailiac site in 55%. Serum triglyceride levels were increased in 12 of the 18 patients who underwent this test. Oral glucose tolerance test results were normal in all 20 patients. Conclusion. Sixty-five percent of our patients with juvenile DM were found to have loss of subcutaneous fat on quantification compared with 40% on physical appearance alone. Maximum fat loss occurred at the mid-axillary skinfold site. A significant number of patients with juvenile DM (66%) had hypertriglyceridemia. We hypothesize that lipodystrophy and hypertriglyceridemia could well be integral components of what may be an expanded juvenile DM syndrome.

Revue / Journal Title

Arthritis care and research   ISSN 0893-7524   CODEN ARCREG 

Source / Source

2006, vol. 55, n^o4, pp. 564-568 [5 page(s) (article)] (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams and Wilkins, Hagerstown, MD, ETATS-UNIS  (1988) (Revue)

Mots-clés anglais / English Keywords

Masculinization ; Endocrinopathy ; Hyperlipoproteinemia ; Dyslipemia ; Metabolic diseases ; Enzymopathy ; Adipose tissue disorders ; Immunopathology ; Connective tissue disease ; Skin disease ; Striated muscle disease ; Systemic disease ; Autoimmune disease ; Human ; Lipoprotein ; Hair ; Triglyceride ; Lipids ; Rheumatology ; Skinfold thickness ; Lipodystrophy ; Dermatomyositis ; Child ; Adipose tissue ; Hirsutism ; Hypertriglyceridemia ;

Mots-clés français / French Keywords

Masculinisation ; Endocrinopathie ; Hyperlipoprotéinémie ; Dyslipémie ; Métabolisme pathologie ; Enzymopathie ; Tissu adipeux pathologie ; Immunopathologie ; Tissu conjonctif pathologie ; Peau pathologie ; Muscle strié pathologie ; Maladie système ; Maladie autoimmune ; Homme ; Lipoprotéine ; Poil ; Triglycéride ; Lipide ; Rhumatologie ; Pli cutané ; Lipodystrophie ; Dermatomyosite ; Enfant ; Tissu adipeux ; Hirsutisme ; Hypertriglycéridémie ;

Mots-clés espagnols / Spanish Keywords

Masculinizacion ; Endocrinopatía ; Hiperlipoproteinemia ; Dislipemia ; Metabolismo patología ; Enzimopatía ; Tejido adiposo patología ; Inmunopatología ; Tejido conjuntivo patología ; Piel patología ; Músculo estriado patología ; Enfermedad sistémica ; Enfermedad autoinmune ; Hombre ; Lipoproteina ; Pelo ; Triglicérido ; Lípido ; Reumatología ; Pliegue cutáneo ; Lipodistrofia ; Dermatomiositis ; Niño ; Tejido adiposo ; Hirsutismo ; Hipertrigliceridemia ;

Mots-clés d'auteur / Author Keywords

Juvenile dermatomyositis ; Lipodystrophy ; Skinfold thickness ; Hypertriglyceridemia ; Hirsutism ;

Localisation / Location

INIST-CNRS, Cote INIST : 21540, 35400014227749.0080