Titre du document / Document title

Detection of parasitemia profiles by blood culture after treatment of human chronic Trypanosoma cruzi infection

Auteur(s) / Author(s)

DE CASTRO Ana Maria ⁽¹⁾ ; OSTERMAYER LUQUETTI Alejandro ⁽¹⁾ ; RASSI Anis ⁽²⁾ ; CHIARI Egler ⁽³⁾ ; DA CUNHA GALVAO Lucia Maria ⁽³⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Departamento de Microbiologia, Imunologia, Parasitologia e Patologia do Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, BRESIL
⁽²⁾ Departamento de Clínica Médica, Faculdade de Medicina-Universidade Federal de Goiás, Goiânia, GO, BRESIL
⁽³⁾ Laboratório de Biologia do Trypanosoma cruzi, Departamento de Parasitologia, Instituto de Ciências Biológicas-Universidade Federal de Minas Gerais, Belo Horizonte, MG, BRESIL

Résumé / Abstract

The change in parasitemia profile, measured by sequential blood cultures of 27 benznidazole (Bz) treated patients compared with 13 untreated patients, on the chronic phase of chagas disease, is described. All patients were adults (age limits: 23-88) with positive serology (three tests); 23 of them were females. All patients were submitted to six blood cultures, three before and three after Bz treatment. The parasitemia was classified as nondetected (with three negative blood cultures), medium (one positive culture in three), and high (two or three positive cultures). From the eight patients with nondetected parasitemia before Bz, seven still had the same profile and only one switched to medium; from eight with medium parasitemia, seven shifted to nondetected, and one to high parasitemia. From the 11 patients with high parasitemia before Bz, ten converted to nondetected and only one was positive after Bz. Nineteen of the 27 patients changed the parasitemia profile (70.4%), and the rate of therapeutic failure was 11.1% (3/27) during the first 24 months of follow-up after Bz. The shift to nondetected parasitemia profile was from 8/27 to 24/27 patients after Bz treatment for the first 2 years. Only 46.2% (6/13) of the nontreated individuals changed the parasitemia profile. We conclude that there is a strong trypanocide effect of Bz (88.8%) and a rate of therapeutic failure of 11.1 % during the first 2 years after trypanocidal treatment.

Revue / Journal Title

Parasitology research   ISSN 0932-0113   CODEN PARREZ 

Source / Source

2006, vol. 99, n^o4, pp. 379-383 [5 page(s) (article)] (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

Springer, Berlin, ALLEMAGNE  (1987) (Revue)

Mots-clés anglais / English Keywords

Protozoa ; Kinetoplastida ; Infection ; Parasitosis ; Parasite ; Trypanosoma cruzi ; Chronic ; Human ; Culture ; Blood ; Parasitemia ; Detection ;

Mots-clés français / French Keywords

Protozoa ; Kinetoplastida ; Infection ; Parasitose ; Parasite ; Trypanosoma cruzi ; Chronique ; Homme ; Culture ; Sang ; Parasitémie ; Détection ;

Mots-clés espagnols / Spanish Keywords

Protozoa ; Kinetoplastida ; Infección ; Parasitosis ; Parásito ; Trypanosoma cruzi ; Crónico ; Hombre ; Cultivo ; Sangre ; Parasitemia ; Detección ;

Localisation / Location

INIST-CNRS, Cote INIST : 5859, 35400014227038.0140