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Titre du document / Document title

Isolation and biomimetic synthesis of anti-inflammatory stilbenolignans from Gnetum cleistostachyum

Auteur(s) / Author(s)

YAO Chun-Suo ; LIN Mao ; WANG Lin ;

Résumé / Abstract

One new stilbenolignan, gnetucleistol F (1), and four known stilbenolignans, gnetofuran A (2), lehmbachol D (3), gnetifolin F (4) and gnetumontanin C (5) were isolated from the lianas of Gnetum cleistostachyum C. Y. CHENG (Gnetaceae). Their structures and relative configurations were determined by means of spectroscopic evidence. Compounds 1, 2, 3 and 4 were synthesized for the first time on the basis of their biogenetic pathway, and their possible biomimetical synthetic mechanisms were discussed. The pharmacological activities of all stilbenolignans have been tested. Among them, 1, 2, 3, 4 and 5 showed moderate inhibitory activities on TNF-α and 1 also showed potent inhibitory activity on malondialdehyde.

Revue / Journal Title

Chemical and pharmaceutical bulletin    ISSN  0009-2363   CODEN CPBTAL 

Source / Source

2006, vol. 54, no7, pp. 1053-1057 [5 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

JAACC, Tokyo, JAPON  (1958) (Revue)

Mots-clés d'auteur / Author Keywords

Gnetum cleistostachyum

;

Gnetaceae

;

gnetucleistol F

;

TNF-a activity

;

stilbenolignan

;

Localisation / Location

INIST-CNRS, Cote INIST : 4123, 35400014228952.0280

Nº notice refdoc (ud4) : 18028605



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