RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Four dengue virus serotypes found circulating during an outbreak of dengue fever and dengue haemorrhagic fever in Jakarta, Indonesia, during 2004

Auteur(s) / Author(s)

SUWANDONO Agus (1) ; KOSASIH Herman (2) ; NURHAYATI (2) ; KUSRIASTUTI Rita (3) ; HARUN Syahrial (1) ; MA'ROEF Chairin (2) ; WURYADI Suharyono (2) ; HERIANTO Bambang (1) ; YUWONO Djoko (1) ; PORTER Kevin R. (4) ; BECKETT Charmagne G. (4) ; BLAIR Patrick J. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) National Institute of Health Research and Development, Ministry of Health, Jakarta, INDONESIE
(2) Viral Diseases Program, U.S. Naval Medical Research Unit #2, Jakarta, INDONESIE
(3) Arbovirus Sub-directorate, Communicable Disease Center, Ministry of Health, Jakarta, INDONESIE
(4) Naval Medical Research Center, Silver Spring, MD, ETATS-UNIS

Résumé / Abstract

Periodic outbreaks of dengue have emerged in Indonesia since 1968, with the severity of resulting disease increasing in subsequent years. In early 2004, a purported dengue outbreak erupted across the archipelago, with over 50000 cases and 603 deaths reported. To confirm the disease aetiology and to provide an epidemiological framework of this epidemic, an investigation was conducted in ten hospitals within the capital city of Jakarta. Clinical and laboratory findings were determined from a cohort of 272 hospitalised patients. Exposure to dengue virus was determined in 180 (66.2%) patients. When clinically assessed, 100 (55.6%) of the 180 patients were classified as having dengue fever (DF), 31 (17.2%) as DF with haemorrhagic manifestations and 49 (27.2%) as dengue haemorrhagic fever (DHF). Evidence from haemagglutination inhibition assays suggested that 33/40 (82.5%) of those with DHF from which laboratory evidence was available suffered from a secondary dengue infection. All four dengue viruses were identified upon viral isolation, with DEN-3 being the most predominant serotype recovered, followed by DEN-4, DEN-2 and DEN-1. In summary, the 2004 outbreak of dengue in Jakarta, Indonesia, was characterised by the circulation of multiple virus serotypes and resulted in a relatively high percentage of a representative population of hospitalised patients developing DHF.

Revue / Journal Title

Transactions of the Royal Society of Tropical Medicine and Hygiene    ISSN  0035-9203   CODEN TRSTAZ 

Source / Source

2006, vol. 100, no9, pp. 855-862 [8 page(s) (article)] (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

Oxford University Press, Oxford, ROYAUME-UNI  (1907) (Revue)

Mots-clés anglais / English Keywords

Hemorrhagic fever

;

Asia

;

Virus

;

Flaviviridae

;

Flavivirus

;

Dengue group virus

;

Infection

;

Viral disease

;

Arbovirus disease

;

Dengue

;

Tropical medicine

;

Epidemiology

;

Indonesia

;

Epidemic

;

Serotype

;

Human

;

Dengue virus

;

Dengue hemorrhagic fever

;

Mots-clés français / French Keywords

Fièvre hémorragique

;

Asie

;

Virus

;

Flaviviridae

;

Flavivirus

;

Virus groupe dengue

;

Infection

;

Virose

;

Arbovirose

;

Dengue

;

Médecine tropicale

;

Epidémiologie

;

Indonésie

;

Epidémie

;

Sérotype

;

Homme

;

Virus dengue

;

Dengue hémorragique

;

Mots-clés espagnols / Spanish Keywords

Fiebre hemorrágica

;

Asia

;

Virus

;

Flaviviridae

;

Flavivirus

;

Dengue group virus

;

Infección

;

Virosis

;

Arbovirosis

;

Dengue

;

Medicina tropical

;

Epidemiología

;

Indonesia

;

Epidemia

;

Serotipo

;

Hombre

;

Dengue virus

;

Dengue hemorrágico

;

Mots-clés d'auteur / Author Keywords

Dengue

;

Dengue virus

;

Dengue haemorrhagic fever

;

Epidemiology

;

Disease outbreak

;

Indonesia

;

Localisation / Location

INIST-CNRS, Cote INIST : 3084, 35400013905311.0100

Nº notice refdoc (ud4) : 17984238



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas