Titre du document / Document title
Four dengue virus serotypes found circulating during an outbreak of dengue fever and dengue haemorrhagic fever in Jakarta, Indonesia, during 2004
Auteur(s) / Author(s)
SUWANDONO Agus (1) ;
KOSASIH Herman (2) ;
NURHAYATI (2) ;
KUSRIASTUTI Rita (3) ;
HARUN Syahrial (1) ;
MA'ROEF Chairin (2) ;
WURYADI Suharyono (2) ;
HERIANTO Bambang (1) ;
YUWONO Djoko (1) ;
PORTER Kevin R. (4) ;
BECKETT Charmagne G. (4) ;
BLAIR Patrick J. (2) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) National Institute of Health Research and Development, Ministry of Health, Jakarta, INDONESIE
(2) Viral Diseases Program, U.S. Naval Medical Research Unit #2, Jakarta, INDONESIE
(3) Arbovirus Sub-directorate, Communicable Disease Center, Ministry of Health, Jakarta, INDONESIE
(4) Naval Medical Research Center, Silver Spring, MD, ETATS-UNIS
Résumé / Abstract
Periodic outbreaks of dengue have emerged in Indonesia since 1968, with the severity of resulting disease increasing in subsequent years. In early 2004, a purported dengue outbreak erupted across the archipelago, with over 50000 cases and 603 deaths reported. To confirm the disease aetiology and to provide an epidemiological framework of this epidemic, an investigation was conducted in ten hospitals within the capital city of Jakarta. Clinical and laboratory findings were determined from a cohort of 272 hospitalised patients. Exposure to dengue virus was determined in 180 (66.2%) patients. When clinically assessed, 100 (55.6%) of the 180 patients were classified as having dengue fever (DF), 31 (17.2%) as DF with haemorrhagic manifestations and 49 (27.2%) as dengue haemorrhagic fever (DHF). Evidence from haemagglutination inhibition assays suggested that 33/40 (82.5%) of those with DHF from which laboratory evidence was available suffered from a secondary dengue infection. All four dengue viruses were identified upon viral isolation, with DEN-3 being the most predominant serotype recovered, followed by DEN-4, DEN-2 and DEN-1. In summary, the 2004 outbreak of dengue in Jakarta, Indonesia, was characterised by the circulation of multiple virus serotypes and resulted in a relatively high percentage of a representative population of hospitalised patients developing DHF.
Revue / Journal Title
Transactions of the Royal Society of Tropical Medicine and Hygiene
ISSN
0035-9203
CODEN TRSTAZ
Source / Source
2006, vol. 100, n
o9, pp. 855-862 [8 page(s) (article)] (30 ref.)
Langue / Language
Anglais
Editeur / Publisher
Oxford University Press, Oxford, ROYAUME-UNI
(1907)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 3084, 35400013905311.0100
Nº notice refdoc (ud4) : 17984238
